Chemicals list & Research Gallery

Isoxazole
CAS number: 288-14-2
Isoxazole is a monocyclic heteroarene with a structure consisting of a 5-membered ring containing three carbon atoms and an oxygen and nitrogen atom adjacent to each other. It is the parent of the class of isoxazoles. It is a mancude organic heteromonocyclic parent, a monocyclic heteroarene and a member of isoxazoles.
Evolution of isoxazole-based anti-TB agents
Evolution of isoxazole-based anti-TB agents
Synthesis of isoxazoles 6 via [3 + 2] cycloaddition of nitrile oxide 4 onto vinyl ether 2.
Synthesis of isoxazoles 6 via [3 + 2] cycloaddition of nitrile oxide 4 onto vinyl ether 2.
Synthesis of isoxazoles 10 via Suzuki coupling and [3 + 2] cycloaddition of nitrile oxides onto vinyl ether 2.
Synthesis of isoxazoles 10 via Suzuki coupling and [3 + 2] cycloaddition of nitrile oxides onto vinyl ether 2.
1H-1,2,3-Triazole
CAS number: 288-36-8
1H-1,2,3-Triazole is one of the four aromatic heterocyclic compounds with two carbon atoms, three nitrogen atoms, and two double bonds.
Selected useful 1,2,3-triazoles with a 5-sulfur substituent.
Selected useful 1,2,3-triazoles with a 5-sulfur substituent.
General structures of (a) a peptide and (b) a 1H-1,2,3-triazole-modified peptidomimetics.
General structures of (a) a peptide and (b) a 1H-1,2,3-triazole-modified peptidomimetics.
Oxazole
CAS number: 288-42-6
Oxazole is a vital heterocycle moiety, devouring effective healing action with three loci for substitution.
We performed a series of systematic structure–activity relationship (SAR) studies on 2 , exploring the 4- and 5-positions of the central oxazole, the C2 acyl side chain, and the central heterocyclic ring, and found that each independently affects the potency or selectivity of the inhibitor, Figure 2 .
We performed a series of systematic structure–activity relationship (SAR) studies on 2 , exploring the 4- and 5-positions of the central oxazole, the C2 acyl side chain, and the central heterocyclic ring, and found that each independently affects the potency or selectivity of the inhibitor, Figure 2 .
Synthesis of oxazole-based inhibitors bearing a C5 aryl substituent and containing additional conformational constraints in the C2 acyl side chain.
Synthesis of oxazole-based inhibitors bearing a C5 aryl substituent and containing additional conformational constraints in the C2 acyl side chain.
The synthesis of candidate inhibitors that bear a nonaro-matic oxazole C5-substituent.
The synthesis of candidate inhibitors that bear a nonaro-matic oxazole C5-substituent.
Stille coupling with 2-bromopyridine produced the C5-substituted oxazoles, which were converted to the corresponding ketones by TBS ether deprotection (Bu4NF) and oxidation of the liberated alcohols using Dess-Martin Periodinane.
Stille coupling with 2-bromopyridine produced the C5-substituted oxazoles, which were converted to the corresponding ketones by TBS ether deprotection (Bu4NF) and oxidation of the liberated alcohols using Dess-Martin Periodinane.
Oxazole Fragment Synthesis
Oxazole Fragment Synthesis
Thiazole
CAS number: 288-47-1
Thiazole is a mancude organic heteromonocyclic parent, a member of 1,3-thiazoles and a monocyclic heteroarene.
General synthesis of thiazole-based derivatives.
General synthesis of thiazole-based derivatives.
1H-1,2,4-Triazole
CAS number: 288-88-0
1H-1,2,4-triazole is a 1,2,4-triazole. It is a tautomer of a 3H-1,2,4-triazole and a 4H-1,2,4-triazole.
Examples of some bioactive compounds containing 1,2,4-triazole moiety.
Examples of some bioactive compounds containing 1,2,4-triazole moiety.
Synthesis of 1,2,4-triazole and 4,5-disubstituted-imidazole L-ascorbic acid (1, 2, 3, 5, 6 and 9) and imino-ascorbic acid (4, 7 and 8) derivatives.
Synthesis of 1,2,4-triazole and 4,5-disubstituted-imidazole L-ascorbic acid (1, 2, 3, 5, 6 and 9) and imino-ascorbic acid (4, 7 and 8) derivatives.
1H-Tetrazole
CAS number: 288-94-8
1H-tetrazole is a tetrazole tautomer where the proton is located on the 1st position. It is a tetrazole and a one-carbon compound. It is a tautomer of a 2H-tetrazole and a 5H-tetrazole.
IR difference spectrum after 1 min photolysis (254 nm) of 5-phenyltetrazole 2 in Ar matrix at 12 K. Positive peaks: photolysis products, largely benzonitrile imine 6; the peak near 1700 cm−1 is due to an impurity on the deposition window. Negative peaks: reacted tetrazole 2.
IR difference spectrum after 1 min photolysis (254 nm) of 5-phenyltetrazole 2 in Ar matrix at 12 K. Positive peaks: photolysis products, largely benzonitrile imine 6; the peak near 1700 cm−1 is due to an impurity on the deposition window. Negative peaks: reacted tetrazole 2.
1,3,4-Oxadiazole
CAS number: 288-99-3
1,3,4-Oxadiazole is a five-membered heterocyclic aromatic compound containing one oxygen atom and two nitrogen atoms, positioned at the 1, 3, and 4 positions. It's a key structural motif in many biologically active molecules and is known for its diverse pharmacological properties.
The preparation of a representative small series of 1,3,4-oxadiazoles containing the 6-phenoxy-1,2,3,4-tetrahydronaphthalene side chain was conducted.
The preparation of a representative small series of 1,3,4-oxadiazoles containing the 6-phenoxy-1,2,3,4-tetrahydronaphthalene side chain was conducted.
Pyrimidine
CAS number: 289-95-2
Pyrimidines (“m-diazine”) were known as the breakdown products of uric acid.
Bioactive 4H-chromene and pyrimidine-fused heterocycles.
Bioactive 4H-chromene and pyrimidine-fused heterocycles.
Oleic acid catalysed pyrimidine-fused heterocycles synthesis.
Oleic acid catalysed pyrimidine-fused heterocycles synthesis.
Pseudo three-component synthesis of pyrimidine-fused heterocycles.
Pseudo three-component synthesis of pyrimidine-fused heterocycles.
Triazine
CAS number: 289-96-3
1,2,3-triazine is a triazine.
Synthesis of triazine dimers 1–47. Reagents and conditions: (a) diaminoalkanes/diaminobenzene/piperazine, DIPEA, dry dioxane, 110 °C.
Synthesis of triazine dimers 1–47. Reagents and conditions: (a) diaminoalkanes/diaminobenzene/piperazine, DIPEA, dry dioxane, 110 °C.
Argadin
CAS number: 289665-92-5
Argadin is a cyclic peptide natural product, investigated for its ability to be a nanomolar inhibitor of Family-18 Chitinases.
Chitin 1, allosamidin 2, argifin 3 and argadin 4.
Chitin 1, allosamidin 2, argifin 3 and argadin 4.