Chemicals list & Research Gallery

Carbamate
CAS number: 302-11-4
Carbamate is an amino-acid anion. It is a conjugate base of a carbamic acid.
Carbamate-linked cyclopropene sugars label cellular glycoproteins.
Carbamate-linked cyclopropene sugars label cellular glycoproteins.
ORTEP plot of carbamate derivative 9.
ORTEP plot of carbamate derivative 9.
Possible configuration at the C-12 and C-13 positions in cyclic carbamates.
Possible configuration at the C-12 and C-13 positions in cyclic carbamates.
5-Nitroimidazole
CAS number: 3034-38-6
5-Nitroimidazole is a nitrogen heterocyclic compound that is a key component in the development of various drugs with antimicrobial, antiparasitic, and antiviral properties.
Nitroimidazole drug candidates for tuberculosis.
Nitroimidazole drug candidates for tuberculosis.
Tubulysin D
CAS number: 309935-57-7
Tubulysin D is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin D can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis.
Tubulysin D (1).
Tubulysin D (1).
Aminoquinoline
CAS number: 31135-62-3
An antimalarial drug used to treat susceptible infections with P. vivax, P. malariae, P. ovale, and P. falciparum.
Retrosynthesis of 6-Substituted 2-Aminoquinolines
Retrosynthesis of 6-Substituted 2-Aminoquinolines
Equilibrium binding dissociation constants (Kd) of some 2-aminoquinolines reported previously.
Equilibrium binding dissociation constants (Kd) of some 2-aminoquinolines reported previously.
Trichloromethyl
CAS number: 3170-80-7
Trichloromethane is an organic chemical compound also known as chloroform. It is a volatile, colorless liquid with a sweet, ether-like odor. While historically used as an anesthetic, its main uses today are as a solvent, a chemical intermediate in various industrial processes, and a precursor in the production of refrigerants and PTFE.
Although phosphonate 6 was acid labile and decomposed overnight in chloroform, it still underwent efficient cross-coupling reactions.
Although phosphonate 6 was acid labile and decomposed overnight in chloroform, it still underwent efficient cross-coupling reactions.
Calcitriol
CAS number: 32222-06-3
Calcitriol is a medication that treats low calcium levels caused by kidney disease. It can also treat parathyroid gland conditions.
Enantioselective synthesis of a key A-ring intermediate for the preparation of 1α,25-dihydroxyvitamin D3
Enantioselective synthesis of a key A-ring intermediate for the preparation of 1α,25-dihydroxyvitamin D3
α,β-Unsaturated aldehyde 1 serves as a key intermediate in the synthesis of calcitriol.
α,β-Unsaturated aldehyde 1 serves as a key intermediate in the synthesis of calcitriol.
Structures of 1α,25-dihydroxyvitamin D3 (1) (and its 2R-substituted analogues 2-4), ED-71, and 20-epi-1 (and its 2R-substituted analogues 20-epi-2a and 20-epi-4a -c).
Structures of 1α,25-dihydroxyvitamin D3 (1) (and its 2R-substituted analogues 2-4), ED-71, and 20-epi-1 (and its 2R-substituted analogues 20-epi-2a and 20-epi-4a -c).
Structures of 1,25-(OH)2D3 (1) and Vitamin D Analogues
Structures of 1,25-(OH)2D3 (1) and Vitamin D Analogues
Inhibitory effect on the transactivation induced by 1,25-(OH)2D3 (1) was evaluated.
Inhibitory effect on the transactivation induced by 1,25-(OH)2D3 (1) was evaluated.
RXRR and SRC-1 recruitment to VDR by 1,25-(OH)2D3 (1) and synthetic compounds (3a-c, 4a-c, 5a-c, and 6a-c) in Cos7 cells.
RXRR and SRC-1 recruitment to VDR by 1,25-(OH)2D3 (1) and synthetic compounds (3a-c, 4a-c, 5a-c, and 6a-c) in Cos7 cells.
Diazomethane
CAS number: 334-88-3
Diazomethane, a yellow gas normally used as a solution in ether, readily esterifies fatty acids in the presence of methanol at room temperature. It is a strong respiratory irritant. Diazomethane is usually prepared by the decomposition of various derivatives of N-methyl-N-nitrosoamines.
Quantum chemically computed Gibbs free-energy pathway for the cyclopropanation of DVTMS by diazomethane.
Quantum chemically computed Gibbs free-energy pathway for the cyclopropanation of DVTMS by diazomethane.
Quantum chemically computed lowest Gibbs free-energy pathway for the palladium(0)-catalyzed cy-clopropanation of trimethylvinylsilane by diazomethane.
Quantum chemically computed lowest Gibbs free-energy pathway for the palladium(0)-catalyzed cy-clopropanation of trimethylvinylsilane by diazomethane.
Cycle for the palladium-catalyzed cyclopropanation of DVTMS by diazomethane according to experimental observations and DFT calculations.
Cycle for the palladium-catalyzed cyclopropanation of DVTMS by diazomethane according to experimental observations and DFT calculations.
1-Methoxy-1,3-cyclohexadien-5-yne
CAS number: 33543-19-0
1-methoxycyclohexa-1,3-dien-5-yne is a benzyne. It derives from a hydride of a 1,2-didehydrobenzene.
Electronic and steric factors in the reaction of P-vinyl- λ5-phosphazenes and 3-methoxybenzyne.
Electronic and steric factors in the reaction of P-vinyl- λ5-phosphazenes and 3-methoxybenzyne.
Cysteine
CAS number: 3374-22-9
Cysteine is a semi-essential amino acid with a sulfur-containing side chain.
Blue and green tppts (2.0 mM) or cysteine (1.0 mM) were added to FeIII(TPPS) (1, 10 μM) and nitrite (10 mM) solutions, respectively, and the reactions were monitored by using NOA monitoring to determine NO formation (dots) and by time absorbance at 413 nm, λmax of FeII(TPPS)(NO) (2) (lines).
Blue and green tppts (2.0 mM) or cysteine (1.0 mM) were added to FeIII(TPPS) (1, 10 μM) and nitrite (10 mM) solutions, respectively, and the reactions were monitored by using NOA monitoring to determine NO formation (dots) and by time absorbance at 413 nm, λmax of FeII(TPPS)(NO) (2) (lines).
Synthesis of TP10-SS-Flu-ITAM (5). The TP10-carrier was first prepared on the resin with the Fmoc-Lys(Boc-Cys(Trt))-OH (20) building block incorporated into the sequence (seventh residue from the N-terminus). During cleavage and deprotection the cysteine was activated, yielding TP10-Cys(pNpys) (22). This carrier was conjugated to cargo Flu-ITAM (30) to yield the construct 5.
Synthesis of TP10-SS-Flu-ITAM (5). The TP10-carrier was first prepared on the resin with the Fmoc-Lys(Boc-Cys(Trt))-OH (20) building block incorporated into the sequence (seventh residue from the N-terminus). During cleavage and deprotection the cysteine was activated, yielding TP10-Cys(pNpys) (22). This carrier was conjugated to cargo Flu-ITAM (30) to yield the construct 5.
Palladium diacetate
CAS number: 3375-31-3
Palladium acetate is a chemical compound of palladium. It is used as a catalyst for many organic reactions and as a precursor to other palladium(II) compounds. It has now been found that palladium diacetate can be prepared in crystalline form free of undesired contaminants such as palladium hydroxy acetate by reaction of specially prepared hydrous palladium oxide (referred to hereinafter as HPO).
Possible compounds that may obtained by reaction of palladium acetate with TnInA, this ligand acting as a bidentate one.
Possible compounds that may obtained by reaction of palladium acetate with TnInA, this ligand acting as a bidentate one.
Pd(II)-Catalyzed Coupling of Imine and Alkynylbenziodoxolone (PMP = p-MeOC6H4)
Pd(II)-Catalyzed Coupling of Imine and Alkynylbenziodoxolone (PMP = p-MeOC6H4)
Next, the role of Pd(OAc)2 in our new reaction was investigated (Scheme 4)
Next, the role of Pd(OAc)2 in our new reaction was investigated (Scheme 4)
Preparative synthesis of 11 on a 1.5 g scale.
Preparative synthesis of 11 on a 1.5 g scale.