Chemicals list & Research Gallery

Corilagin
CAS number: 23094-69-1
Corilagin, a gallotannin, is one of the major active components of many ethnopharmacological plants. It was isolated from Caesalpinia coriaria (Jacq.)
Retrosynthetic Approach to Corilagin (1)
Retrosynthetic Approach to Corilagin (1)
Synthesis of Corilagin (1)
Synthesis of Corilagin (1)
Febrifugine
CAS number: 24159-07-7
Febrifugine, a quinazolinone alkaloid that inhibits P. falciparum and has antimalarial activity, is an excellent compound that can be used to block the proliferation of malarial parasites.
Initial approaches to febrifugine.
Initial approaches to febrifugine.
Synthesis of (+)-febrifugine.
Synthesis of (+)-febrifugine.
Synthesis of ent-febrifugine.
Synthesis of ent-febrifugine.
Biologically active β-hydroxy piperidines.
Biologically active β-hydroxy piperidines.
Cyclopropyl radical
CAS number: 2417-82-5
Cyclopropyl radical is a highly reactive organic intermediate characterized by a three-membered cyclopropane ring bearing an unpaired electron on one of the carbon atoms.
LED-mediated cyclopropane synthesis. [a] Using trans-b-methylstyrene. [b] Using cis-b-methylstyrene. [c] 20 equiv of styrene. [d] Violet LED used. Also 27% of malonate dimer by H NMR. 1[e] Using soluble ylide 1o.
LED-mediated cyclopropane synthesis. [a] Using trans-b-methylstyrene. [b] Using cis-b-methylstyrene. [c] 20 equiv of styrene. [d] Violet LED used. Also 27% of malonate dimer by H NMR. 1[e] Using soluble ylide 1o.
Fucose
CAS number: 2438-80-4
Fucose is an unusual sugar that is present in a variety of glycolipids and glycoproteins produced by mammalian cells.
Glycomimetic scaffolds designed to mimic (A) mannose and (B) fucose. Hydroxyl groups typically involved in C-type lectin binding are highlighted in red.
Glycomimetic scaffolds designed to mimic (A) mannose and (B) fucose. Hydroxyl groups typically involved in C-type lectin binding are highlighted in red.
Preparation of Fucose-Saccharosamine Disaccharide Glycals 11-12 and 14-15
Preparation of Fucose-Saccharosamine Disaccharide Glycals 11-12 and 14-15
4H-chromene
CAS number: 254-03-5
4H-chromene is a simplest member of the class of chromene in which the heterocyclic pyran ring has a double bond between positions 2 and 3. It is a chromene and an organic heterobicyclic compound. It is a tautomer of a 2H-chromene.
Bioactive 4H-chromene and pyrimidine-fused heterocycles.
Bioactive 4H-chromene and pyrimidine-fused heterocycles.
Oleic acid catalysed 4H-chromene synthesis.
Oleic acid catalysed 4H-chromene synthesis.
Synthesized 4H-chromene derivatives.
Synthesized 4H-chromene derivatives.
Oleic acid catalysed 4H-chromene synthesis by three-component reaction.
Oleic acid catalysed 4H-chromene synthesis by three-component reaction.
1-Hydroxybenzotriazole
CAS number: 2592-95-2
1-Hydroxybenzotriazole is a coupling reagent used to synthesize amides by the condensation reaction between the activated ester/acid and the amino group of protected amino acids. It is also used as a racemization suppressor during peptide synthesis.
Attempted amino acid coupling: glycine ethyl ester, N,N'-dicyclohexyl carbodiimide (DCCI) or 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDAC), 1-hydroxybenzotriazole (HOBt), water, room temperature.
Attempted amino acid coupling: glycine ethyl ester, N,N'-dicyclohexyl carbodiimide (DCCI) or 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDAC), 1-hydroxybenzotriazole (HOBt), water, room temperature.
Synthesis of Dap dipeptides.
Synthesis of Dap dipeptides.
2-Phenylindoline
CAS number: 26216-91-1
2-Phenylindoline is a partially saturated derivative of indole, characterized by a fused benzene and pyrrolidine ring system.
Resolution of racemic 2-phenylindoline (8).
Resolution of racemic 2-phenylindoline (8).
Sodium azide
CAS number: 26628-22-8
Sodium azide is the sodium salt of hydrogen azide (hydrazoic acid). It is a fast acting, potentially deadly chemical that is an odorless white solid.
Addition–elimination mechanism for a classical SNAr reaction for para-halogenated nitrobenzene with sodium azide
Addition–elimination mechanism for a classical SNAr reaction for para-halogenated nitrobenzene with sodium azide
SNAr reaction of halogenated benzene with sodium azide under phase-transfer conditions
SNAr reaction of halogenated benzene with sodium azide under phase-transfer conditions
Concerted mechanism for a SNAr reaction for p-Iodo nitrobenzene with sodium azide under mw irradiation
Concerted mechanism for a SNAr reaction for p-Iodo nitrobenzene with sodium azide under mw irradiation
Product obtained in the reaction of pF compounds (R = COH, COCH3) with an excess of sodium azide under different experimental conditions
Product obtained in the reaction of pF compounds (R = COH, COCH3) with an excess of sodium azide under different experimental conditions
Proposed free energy diagrams for the SNAr reactions of sodium azide with different pF compounds.
Proposed free energy diagrams for the SNAr reactions of sodium azide with different pF compounds.
Xanthatin
CAS number: 26791-73-1
Xanthatin is a sesquiterpene lactone. Xanthatin, a sesquiterpene lactone purified from Xanthium strumarium L., possesses a significant antitumor role in several malignant tumors.
Retrosynthetic analysis of xanthatin.
Retrosynthetic analysis of xanthatin.
Synthesis of the bicyclic core structure 2 of xanthatin.
Synthesis of the bicyclic core structure 2 of xanthatin.
Final steps in the synthesis of xanthatin 1a and side-chain analogues 1b–c.
Final steps in the synthesis of xanthatin 1a and side-chain analogues 1b–c.
1H-Indazole
CAS number: 271-44-3
1H-indazole is an indazole. It is a tautomer of a 2H-indazole.
Improved Preparation of 2 from Indazole 7
Improved Preparation of 2 from Indazole 7
An Improved Preparation of Indazole 2
An Improved Preparation of Indazole 2
Some drugs and drug candidates containing the 1H-indazole structure.
Some drugs and drug candidates containing the 1H-indazole structure.
The reported strategies for the synthesis of 1H-indazoles.
The reported strategies for the synthesis of 1H-indazoles.
Biologically active compounds containing indazole, indazolone, tetrahydroindazolone, or N-acyl pyrrolidine moieties.
Biologically active compounds containing indazole, indazolone, tetrahydroindazolone, or N-acyl pyrrolidine moieties.