Chemicals list & Research Gallery

Fatty acids
CAS number: 67254-79-9
Fatty acids, one class of essential nutrients for humans, are an important source of energy and an essential component of cell membranes. Most fatty acids in plants and animals have an even carbon number and no branching. One or more double bonds may occur, mostly in cis configuration. More than 40 different fatty acids are commonly encountered in foods.
N-Substituted pantothenamides (such as N-pentyl pan- tothenamide shown above) act as antimetabolites by forming coenzyme A analogues which do not contain the essential terminal thiol group of natural CoA. These analogues subsequently transfer inactive prosthetic groups to the acyl carrier proteins that are involved in fatty acid metabolism, thereby blocking these processes.
N-Substituted pantothenamides (such as N-pentyl pan- tothenamide shown above) act as antimetabolites by forming coenzyme A analogues which do not contain the essential terminal thiol group of natural CoA. These analogues subsequently transfer inactive prosthetic groups to the acyl carrier proteins that are involved in fatty acid metabolism, thereby blocking these processes.
Dipyrone
CAS number: 68-89-3
Dipyrone, also known as metamizole, is a pain reliever (analgesic) and fever reducer (antipyretic) that is used to treat moderate to severe pain and fever. It is available in various forms like oral tablets, suppositories, and injections. While widely used in many countries, it has been banned or restricted in some, including the United States, due to concerns about potentially serious side effects like agranulocytosis (a severe reduction in white blood cells).
Metabolites of dipyrone (1).
Metabolites of dipyrone (1).
Concentrations of 5 (A) and 6 (B) in the brain of wild-type mice (FAAH+/+) and of FAAH knockout mice (FAAHÀ/À) after administration of dipyrone or water for five days (n = 3 mice/group, mean SEM).
Concentrations of 5 (A) and 6 (B) in the brain of wild-type mice (FAAH+/+) and of FAAH knockout mice (FAAHÀ/À) after administration of dipyrone or water for five days (n = 3 mice/group, mean SEM).
Burkholderia cepacia
CAS number: 68332-96-7
Burkholderia cepacia is a plant phytogen and is known as a hardy and versatile organism.
EMDee assay of allylic acetate 2 using the lipase from Pseudomonas cepacia.
EMDee assay of allylic acetate 2 using the lipase from Pseudomonas cepacia.
Plot of the rate of the lipase-catalyzed reaction as a function of the concentration of (R)-2.
Plot of the rate of the lipase-catalyzed reaction as a function of the concentration of (R)-2.
Analysis of 88 samples of compound 2 that range in ee from 100% (S) to 100% (R) using the lipase from Pseudomonas cepacia.
Analysis of 88 samples of compound 2 that range in ee from 100% (S) to 100% (R) using the lipase from Pseudomonas cepacia.
Structures of several substrates for the lipase from Pseudomonas cepacia.
Structures of several substrates for the lipase from Pseudomonas cepacia.
Carboxylic acids, C2-3
CAS number: 68475-71-8
Carboxylic acids, C2–3 is a low-molecular-weight carboxylic acids containing two to three carbon atoms, primarily including acetic acid (C2) and propionic acid (C3).
Carbazole was directly coupled with excess 1,4-dibromobutane under strong alkaline conditions to give 9-(4-bromobutane)carbazole (1). 4-(p-bromophenyl)-6-phenyl-2,2′-bipyridine was synthesized by the Kröhnke method. A strong palladium-catalyzed Buchwald method and an efficient Pd(OAc)2/DPEphos catalyst/ligand system were used to promote the condensation of aniline with 4-(p-bromophenyl)-6-phenyl-2,2′-bipyridine. The resulting intermediate (2) was then reacted with 9-(4-bromobutane)carbazole (1) to give the ligand HL (3). The ligand HL (3) and K2PtCl4 were refluxed in glacial acetic acid for 24 h to synthesize the cyclometalated Pt(II) chloride 4 with a yield of more than 80%.
Carbazole was directly coupled with excess 1,4-dibromobutane under strong alkaline conditions to give 9-(4-bromobutane)carbazole (1). 4-(p-bromophenyl)-6-phenyl-2,2′-bipyridine was synthesized by the Kröhnke method. A strong palladium-catalyzed Buchwald method and an efficient Pd(OAc)2/DPEphos catalyst/ligand system were used to promote the condensation of aniline with 4-(p-bromophenyl)-6-phenyl-2,2′-bipyridine. The resulting intermediate (2) was then reacted with 9-(4-bromobutane)carbazole (1) to give the ligand HL (3). The ligand HL (3) and K2PtCl4 were refluxed in glacial acetic acid for 24 h to synthesize the cyclometalated Pt(II) chloride 4 with a yield of more than 80%.
The reactions of substrates 1r and 1s with acetic acid.
The reactions of substrates 1r and 1s with acetic acid.
Synthesis route of HL3 and the corresponding cyclometalated PtII complex [Pt(L3)Cl] ACHTUNRTGNEUNG[PF6]: a) NaH, 1,5-dibromopentane; b) PPh3; c) K2PtCl4, glacial acetic acid.
Synthesis route of HL3 and the corresponding cyclometalated PtII complex [Pt(L3)Cl] ACHTUNRTGNEUNG[PF6]: a) NaH, 1,5-dibromopentane; b) PPh3; c) K2PtCl4, glacial acetic acid.
Pseudomonas syringae, strain ESC-10
CAS number: 68583-32-4
Pseudomonas syringae strain ESC-10 is a naturally occurring bacterium, originally isolated from apples, that is used as a biological control agent to prevent fungal diseases on fruits.
In vitro growth of Pseudomonas syringae (Pst) in the presence of dihydrocarbazine acid (DHCA), carbazine acid, or DHCA analogs
In vitro growth of Pseudomonas syringae (Pst) in the presence of dihydrocarbazine acid (DHCA), carbazine acid, or DHCA analogs
Effects of dihydrocarbamazepine (DHCA) and salicylic acid (SA) on biofilm formation of Pseudomonas syringae (Pst) in vitro
Effects of dihydrocarbamazepine (DHCA) and salicylic acid (SA) on biofilm formation of Pseudomonas syringae (Pst) in vitro
Exogenous infiltration of dihydroindole acid (DHCA) and bacterial quantification of P. syringae in 7-week-old Col-0 and cyp71a12/cyp71a13 rosette leaves.
Exogenous infiltration of dihydroindole acid (DHCA) and bacterial quantification of P. syringae in 7-week-old Col-0 and cyp71a12/cyp71a13 rosette leaves.
Salicylic acid
CAS number: 69-72-7
Salicylic acid is a beta hydroxy acid (BHA) primarily known for its use in skincare, particularly for treating acne and other skin conditions.
Effects of dihydrocarbamazepine (DHCA) and salicylic acid (SA) on biofilm formation of Pseudomonas syringae (Pst) in vitro
Effects of dihydrocarbamazepine (DHCA) and salicylic acid (SA) on biofilm formation of Pseudomonas syringae (Pst) in vitro
4-Methyl-1-pentene
CAS number: 691-37-2
4-Methyl-1-pentene is a hydrocarbon. It appears as a colorless liquid.
Production of 4-methyl-1-pentene catalyzed by complexes 4, 5, 6, and 7.
Production of 4-methyl-1-pentene catalyzed by complexes 4, 5, 6, and 7.
Idealized Catalytic Cycle for 4-Methyl-1-pentene Synthesis
Idealized Catalytic Cycle for 4-Methyl-1-pentene Synthesis
Diisopropylcarbodiimide
CAS number: 693-13-0
Diisopropylcarbodiimide has been used in industry as a stabilizing agent, coupling agent, and condensing agent. The potential for exposure exists during the synthesis of polypeptides and other chemicals in the chemical and pharmaceutical industries, as well as during protein synthesis in the recombinant DNA industry.
Preparation of 2–5. a) pentafluorophenol, 1,3-diisopropylcarbodiimide, CH2Cl2; b) 2-phenylethylamine, 4-aminobutyric acid, or methylamine hydrochloride, iPr2EtN, DMF, 49% (13a), 70% (13b), or 68% (13c) yield for two steps; c) Ac2O, pyridine, then (for 4 and 6) H2O/dioxane, 99% (3), 81% (4), 90% (5), or 97% (6).
Preparation of 2–5. a) pentafluorophenol, 1,3-diisopropylcarbodiimide, CH2Cl2; b) 2-phenylethylamine, 4-aminobutyric acid, or methylamine hydrochloride, iPr2EtN, DMF, 49% (13a), 70% (13b), or 68% (13c) yield for two steps; c) Ac2O, pyridine, then (for 4 and 6) H2O/dioxane, 99% (3), 81% (4), 90% (5), or 97% (6).
Diisopropylethylamine
CAS number: 7087-68-5
N,N-Diisopropylethylamine (DIPEA) is a tertiary amino compound. It is a colorless liquid and is also known as Hunig's base.
Preparation of alkene 14 (DIPEA = N,N-diisopropyl-ethylamine).
Preparation of alkene 14 (DIPEA = N,N-diisopropyl-ethylamine).
Peptoid-synthesis-inspired modular assembly of azaxylylene precursors and their cyclizations. [a] Acetal hydrolysis step is required only in the a (i.e. benzaldehyde) series. [b] Major diastereomer is shown, the minor hydroxy epimer (not shown) is denoted with a prime, 16’a etc. Bn=benzyl, DIPEA=diisopropylethylamine, PTS=pyridinium para-tolue-nesulfonate.
Peptoid-synthesis-inspired modular assembly of azaxylylene precursors and their cyclizations. [a] Acetal hydrolysis step is required only in the a (i.e. benzaldehyde) series. [b] Major diastereomer is shown, the minor hydroxy epimer (not shown) is denoted with a prime, 16’a etc. Bn=benzyl, DIPEA=diisopropylethylamine, PTS=pyridinium para-tolue-nesulfonate.
Synthesis of triazine dimers 1–47. Reagents and conditions: (a) diaminoalkanes/diaminobenzene/piperazine, DIPEA, dry dioxane, 110 °C.
Synthesis of triazine dimers 1–47. Reagents and conditions: (a) diaminoalkanes/diaminobenzene/piperazine, DIPEA, dry dioxane, 110 °C.
Synthesis of β-LEAP. DIPEA=N,N’-diisopropylethylamine, NMM=4-methylmorpholine, HATU=O-(7-azabenzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate, TEA=triethylamine, TFA=trifluoroacetic acid.
Synthesis of β-LEAP. DIPEA=N,N’-diisopropylethylamine, NMM=4-methylmorpholine, HATU=O-(7-azabenzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate, TEA=triethylamine, TFA=trifluoroacetic acid.
Isocyanate
CAS number: 71000-82-3
Cyanate is a pseudohalide anion and an organonitrogen compound. It has a role as a human metabolite. It is a conjugate base of an isocyanic acid and a cyanic acid.
Proposed reaction cycle for coordination complex [M] mediated isocyanate formation from CO, N2 and an electron source.
Proposed reaction cycle for coordination complex [M] mediated isocyanate formation from CO, N2 and an electron source.
Examples of isocyanate formation from the reduction of N2-derived complexes by CO.
Examples of isocyanate formation from the reduction of N2-derived complexes by CO.