Chemicals list & Research Gallery

Protonated arginine
CAS number: 104352-01-4
Protonated arginine refers to the form of the amino acid arginine in which the guanidino group (–C(=NH)NH₂) is fully protonated, carrying a positive charge. This occurs under physiological pH (~7.4), where arginine's side chain remains positively charged due to its high pKa (~12.5).
Synthetic approaches to argifin. Path A: All-solid-phase approach. Path B: Previous combined solid-phase–solution approach.
Synthetic approaches to argifin. Path A: All-solid-phase approach. Path B: Previous combined solid-phase–solution approach.
Tetrabutylammonium
CAS number: 10549-76-5
Tetrabutylammonium is a chemical compound characterized by a positively charged nitrogen atom bonded to four butyl groups (C4H9), forming a quaternary ammonium cation. It's often used in the form of salts with various anions, such as bromide, chloride, fluoride, or perchlorate.
Electrochromic behavior of 3 in THF with tetrabutylammonium perchlorate as the supporting electrolyte at 0.0, −0.5, −0.8, −1.1, −1.4 (V vs Ag/Ag+ as a reference electrode). Platinum was used as the working and counter electrodes.
Electrochromic behavior of 3 in THF with tetrabutylammonium perchlorate as the supporting electrolyte at 0.0, −0.5, −0.8, −1.1, −1.4 (V vs Ag/Ag+ as a reference electrode). Platinum was used as the working and counter electrodes.
Betaine
CAS number: 107-43-7
Betaine is a non-essential amino acid with proven functional properties and underutilized potential.
Schematic diagram showing the possible structural changes of BHMT during the binding process with substrates and products. The blue ovals (S1-S6) represent the different structural states of BMHT monomers. Hcy represents homocysteine, Bet represents betaine, Met represents methionine, Dmg represents dimethylglycine, and TS represents the assumed transition state of the substrate.
Schematic diagram showing the possible structural changes of BHMT during the binding process with substrates and products. The blue ovals (S1-S6) represent the different structural states of BMHT monomers. Hcy represents homocysteine, Bet represents betaine, Met represents methionine, Dmg represents dimethylglycine, and TS represents the assumed transition state of the substrate.
Acetic anhydride
CAS number: 108-24-7
Acetic anhydride is a clear liquid with a pungent, penetrating vinegar-like odor. It is completely miscible with diethyl ether and can be easily dissolved.
Reagents and conditions: (a) ethyl acetoacetate, acetic anhydride, triethylamine, dichloromethane, room temperature, 30 min; (b) trifluroacetic, acetonitrile, room temperature, 45 min; (c) 40 psi H2, 10% Pd=C, methanol, 24 h.
Reagents and conditions: (a) ethyl acetoacetate, acetic anhydride, triethylamine, dichloromethane, room temperature, 30 min; (b) trifluroacetic, acetonitrile, room temperature, 45 min; (c) 40 psi H2, 10% Pd=C, methanol, 24 h.
2,4,6-Trimethylpyridine
CAS number: 108-75-8
2,4,6-Trimethylpyridine, also known as collidine, belongs to the class of organic compounds known as methylpyridines.
Reagents and conditions: i, Ph3CCl, Et3N, CH2Cl2, 92%; ii, LiCMCCH2OTBS (3), THF, BF3?OEt2, 278 uC, 93%; iii, TBSCl, imidazole, DMF; iv, TBAF, THF, 80% from 2; v, Red-Al, Et2O; vi, MsCl, LiCl, collidine, DMF, 0 uC A rt, 83% from 4; vii, LiSnBu3, THF, 278 uC, 93%; viii, TBAF, THF, 79%; ix, Tf2O, collidine, CH2Cl2, Et3N, 288 uC, 99%.
Reagents and conditions: i, Ph3CCl, Et3N, CH2Cl2, 92%; ii, LiCMCCH2OTBS (3), THF, BF3?OEt2, 278 uC, 93%; iii, TBSCl, imidazole, DMF; iv, TBAF, THF, 80% from 2; v, Red-Al, Et2O; vi, MsCl, LiCl, collidine, DMF, 0 uC A rt, 83% from 4; vii, LiSnBu3, THF, 278 uC, 93%; viii, TBAF, THF, 79%; ix, Tf2O, collidine, CH2Cl2, Et3N, 288 uC, 99%.
Reagents and conditions: i, BH3?SMe2, NaBH4 (cat), THF, 88%;ii, Ph3CCl, Et3N, CH2Cl2, 64%; iii, TBSCl, imidazole, DMF, 92%; iv,DIBALH, CH2Cl2, 0 uC, 94%; v, TPAP (cat), NMO, 4 A mol. sieves,CH2Cl2, 78%; vi, (CF3CH2O)2P(O)CH2CO2Me (11), KHMDS, 18-crown-6, THF, 89%; vii, DIBALH, CH2Cl2, 0 uC, 76%; viii, MsCl, LiCl, collidine,DMF, 0 uC A rt, 99%; ix, LiSnBu3, THF, 278 uC, 93%; x, TBAF, THF,collidine, 0 uC A rt, 63%; xi, Tf2O, collidine, CH2Cl2, Et3N, 278 uC, 91%.
Reagents and conditions: i, BH3?SMe2, NaBH4 (cat), THF, 88%;ii, Ph3CCl, Et3N, CH2Cl2, 64%; iii, TBSCl, imidazole, DMF, 92%; iv,DIBALH, CH2Cl2, 0 uC, 94%; v, TPAP (cat), NMO, 4 A mol. sieves,CH2Cl2, 78%; vi, (CF3CH2O)2P(O)CH2CO2Me (11), KHMDS, 18-crown-6, THF, 89%; vii, DIBALH, CH2Cl2, 0 uC, 76%; viii, MsCl, LiCl, collidine,DMF, 0 uC A rt, 99%; ix, LiSnBu3, THF, 278 uC, 93%; x, TBAF, THF,collidine, 0 uC A rt, 63%; xi, Tf2O, collidine, CH2Cl2, Et3N, 278 uC, 91%.
Reagents and conditions: i, LiAlH4, THF; Bu3SnOTf, 0 uC A rt, 83%; ii, 5, PdCl2(MeCN)2, NMP; iii, MsCl, LiCl, collidine, DMF, 0 uC A rt; iv, LiSnBu3, THF, 278 uC, 78% from 15; v, TBAF, THF, Et3N, 72%; vi, Tf2O, collidine, CH2Cl2, Et3N, 278 uC, 99%.
Reagents and conditions: i, LiAlH4, THF; Bu3SnOTf, 0 uC A rt, 83%; ii, 5, PdCl2(MeCN)2, NMP; iii, MsCl, LiCl, collidine, DMF, 0 uC A rt; iv, LiSnBu3, THF, 278 uC, 78% from 15; v, TBAF, THF, Et3N, 72%; vi, Tf2O, collidine, CH2Cl2, Et3N, 278 uC, 99%.
Crebinostat
CAS number: 1092061-61-4
Crebinostat is a Novel Cognitive Enhancer that Inhibits Histone Deacetylase Activity and Modulates Chromatin-Mediated Neuroplasticity.
Crebinostat analogs induce histone H3K9 and H4K12 acetylation in mouse forebrain primary neuronal cultures.
Crebinostat analogs induce histone H3K9 and H4K12 acetylation in mouse forebrain primary neuronal cultures.
Furan
CAS number: 110-00-9
Furan is a heterocyclic organic compound that consists of five aromatic rings that contain four carbon atoms and one oxygen.
The use of furan as imine substituent.
The use of furan as imine substituent.
Thiophene
CAS number: 110-02-1
Thiophene is a monocyclic heteroarene that is furan in which the oxygen atom is replaced by a sulfur. It has a role as a non-polar solvent.
[4+2] and [4+4] cycloadditions of photogenerated azaxylylenes to the furan and thiophene pendant groups. 5’a denotes the minor hydroxy epimer in the thiophene [4+2] cycloadduct. Yields of the isolated products are shown.
[4+2] and [4+4] cycloadditions of photogenerated azaxylylenes to the furan and thiophene pendant groups. 5’a denotes the minor hydroxy epimer in the thiophene [4+2] cycloadduct. Yields of the isolated products are shown.
Synthetic importance of thiophene building blocks.
Synthetic importance of thiophene building blocks.
Current Strategies for the Borylation of Thiophenes
Current Strategies for the Borylation of Thiophenes
Cyclohexane
CAS number: 110-82-7
Cyclohexane is an alicyclic hydrocarbon comprising a ring of six carbon atoms; the cyclic form of hexane, used as a raw material in the manufacture of nylon.
Plots of the fluorescence quantum yields determined in THF/H2O solutions by using 9,10-diphenylanthracene (F=90% in cyclohexane) as the internal standard versus the fraction of water in the solvent. Insets: photo- graphs of the TPE–Ar luminogens in the THF/water mixture (fw =99%) taken under the illumination of a 365 nm UV lamp. Excitation wavelengths [nm]: 320 for TPE–ptol and TPE–mtol, and 310 for the other six fluorophores.
Plots of the fluorescence quantum yields determined in THF/H2O solutions by using 9,10-diphenylanthracene (F=90% in cyclohexane) as the internal standard versus the fraction of water in the solvent. Insets: photo- graphs of the TPE–Ar luminogens in the THF/water mixture (fw =99%) taken under the illumination of a 365 nm UV lamp. Excitation wavelengths [nm]: 320 for TPE–ptol and TPE–mtol, and 310 for the other six fluorophores.
Absorption spectra of 14 in cyclohexane.
Absorption spectra of 14 in cyclohexane.
Fluorescence spectra of 14 in cyclohexane.
Fluorescence spectra of 14 in cyclohexane.
Absorption spectra of 15 in cyclohexane.
Absorption spectra of 15 in cyclohexane.
Fluorescence spectra of 16 in cyclohexane.
Fluorescence spectra of 16 in cyclohexane.
1 Crystal structure of MKC-442 when bound to RT. 2 Structure of cyclohexane-annelated MKC-442 analogue. 3 Structure of cyclopentane-annelated MKC-442 analogue.
1 Crystal structure of MKC-442 when bound to RT. 2 Structure of cyclohexane-annelated MKC-442 analogue. 3 Structure of cyclopentane-annelated MKC-442 analogue.
Absorption and fluorescence spectra of 1 and 5 in cyclohexane at 300 K.
Absorption and fluorescence spectra of 1 and 5 in cyclohexane at 300 K.
TA spectra recorded with 5 in cyclohexane at different time delays after excitation.
TA spectra recorded with 5 in cyclohexane at different time delays after excitation.
Piperidine
CAS number: 110-89-4
Piperidine is an azacycloalkane that is cyclohexane in which one of the carbons is replaced by a nitrogen.
π-Stacking interaction favoring the piperidine system.
π-Stacking interaction favoring the piperidine system.
Synthesis of chiral piperidine.
Synthesis of chiral piperidine.
Synthesis of highly functionalised piperidine 4.
Synthesis of highly functionalised piperidine 4.
Farnesyltransferase active compounds containing piperidine framework.
Farnesyltransferase active compounds containing piperidine framework.
Proposed reaction mechanism for synthesis of highly functionalised piperidines 4.
Proposed reaction mechanism for synthesis of highly functionalised piperidines 4.
Unexpected Opening of the Piperidine Ring
Unexpected Opening of the Piperidine Ring