Chemicals list & Research Gallery

Morphine
CAS number: 57-27-2
Morphine is a non-synthetic narcotic with a high potential for abuse and is derived from opium. It is used for the treatment of pain.
Structure of morphine and its retrosynthetic analysis. TBS = –SiMe2(t-Bu), Tf = –SO2CF3, PMB = –CH2C6H4(p-OMe).
Structure of morphine and its retrosynthetic analysis. TBS = –SiMe2(t-Bu), Tf = –SO2CF3, PMB = –CH2C6H4(p-OMe).
Antinociception in the tail flick assay (52 ℃) following iv administration of 14, 2, and morphine.
Antinociception in the tail flick assay (52 ℃) following iv administration of 14, 2, and morphine.
p-Tolylboronic acid
CAS number: 5720-05-8
p-Tolylboronic acid is used in the development of advanced materials, including polymers and nanomaterials, enhancing properties such as conductivity and strength, which are vital in electronics and coatings.
Rhodium-Catalyzed Asymmetric Addition of p-Tolylboronic Acid (2m) to 1α
Rhodium-Catalyzed Asymmetric Addition of p-Tolylboronic Acid (2m) to 1α
Flavonol
CAS number: 577-85-5
Flavonols are phytoconstituents of biological and medicinal importance.
Flavonoid derivatives used in this study
Flavonoid derivatives used in this study
Synthetic strategy to prepare flavonoid–porphyrin conjugates at β-position.
Synthetic strategy to prepare flavonoid–porphyrin conjugates at β-position.
Synthetic strategy to prepare flavonoid–porphyrin conjugates at meso-position.
Synthetic strategy to prepare flavonoid–porphyrin conjugates at meso-position.
Representative normalized absorption (solid) and fluorescence spectra (dotted) (kexc = 550 nm, OD = 0.02) of flavonoid–porphyrin conjugate 17 in DMF.
Representative normalized absorption (solid) and fluorescence spectra (dotted) (kexc = 550 nm, OD = 0.02) of flavonoid–porphyrin conjugate 17 in DMF.
Plot of the singlet oxygen quantum yield (Ø△) of the flavonoid–porphyrin conjugates versus their fluorescence quantum yield (Øfl) in DMF. The interception of the dotted lines represents the value of the standard (TPP).
Plot of the singlet oxygen quantum yield (Ø△) of the flavonoid–porphyrin conjugates versus their fluorescence quantum yield (Øfl) in DMF. The interception of the dotted lines represents the value of the standard (TPP).
General structure of flavonoids (A) and 3-Hydroxyflavone (Flavonol) (B).
General structure of flavonoids (A) and 3-Hydroxyflavone (Flavonol) (B).
Synthesis of varyingly substituted 3-hydroxyflavone derivatives (1-23).
Synthesis of varyingly substituted 3-hydroxyflavone derivatives (1-23).
Adenosine
CAS number: 58-61-7
Adenosine is used for its antiarrhythmic properties in supraventricular tachycardia (SVT) and can function as a diagnostic tool, depending on the type of SVT.
Chemical structures of adenosine and known ADA inhibitors.
Chemical structures of adenosine and known ADA inhibitors.
Biotin
CAS number: 58-85-5
Biotin is necessary for formation of fatty acids and glucose, which are used as fuels by the body.
Biotin-avidin binding was detected using Xe NMR.
Biotin-avidin binding was detected using Xe NMR.
(A) Structures of ABAO derivatives that contain propargyloxy group and biotin. (B) Quantification of the reaction of BABAO with the M13 phage displaying a library of peptides with N-terminal glyoxal and wt phage displaying no aldehyde (1011 PFU/mL each). (C) Phage mixture was exposed to BABAO for the specified time. (D) To measure the reaction rate, we exposed the mixture of phage to 1 mM BABAO and measured biotinylation as a function of time by avidin capture. Error bars represent standard deviations from four independent kinetics experiments.
(A) Structures of ABAO derivatives that contain propargyloxy group and biotin. (B) Quantification of the reaction of BABAO with the M13 phage displaying a library of peptides with N-terminal glyoxal and wt phage displaying no aldehyde (1011 PFU/mL each). (C) Phage mixture was exposed to BABAO for the specified time. (D) To measure the reaction rate, we exposed the mixture of phage to 1 mM BABAO and measured biotinylation as a function of time by avidin capture. Error bars represent standard deviations from four independent kinetics experiments.
Galactose
CAS number: 59-23-4
Galactose, a member of a group of carbohydrates known as simple sugars (monosaccharides), is a naturally occurring monosaccharide that forms the disaccharide lactose when combined with glucose (another monosaccharide).
The chiral diphosphite ligands with the pyranoside backbone of galactose (L1 and L2) and glucose (L3 and L4).
The chiral diphosphite ligands with the pyranoside backbone of galactose (L1 and L2) and glucose (L3 and L4).
Iodobenzene
CAS number: 591-50-4
Iodobenzene is defined as an aromatic compound that serves as a starting material for the preparation of hypervalent iodine reagents, often alongside ring-substituted analogues such as iodobenzoic acid.
Recycling of catalyst for the reaction of iodobenzene with phenylacetylene.
Recycling of catalyst for the reaction of iodobenzene with phenylacetylene.
Aminocarbonylation of iodobenzene with morpholine.
Aminocarbonylation of iodobenzene with morpholine.
Allyl acetate
CAS number: 591-87-7
Allyl acetate is a flammable liquid and poses a fire hazard. Allyl acetate is a colorless, water-insoluble liquid with a pungent odor.
EMDee assay of allylic acetate 2 using the lipase from Pseudomonas cepacia.
EMDee assay of allylic acetate 2 using the lipase from Pseudomonas cepacia.
Plot of the rate of the lipase-catalyzed reaction as a function of the concentration of (R)-2.
Plot of the rate of the lipase-catalyzed reaction as a function of the concentration of (R)-2.
Preparation and EMDee analysis of 88 samples of crude allylic acetate 2.
Preparation and EMDee analysis of 88 samples of crude allylic acetate 2.
Methylamine hydrochloride
CAS number: 593-51-1
Methylamine hydrochloride is obtained by heating two equivalents of formaldehyde (as formalin) with ammonium chloride at about 100°.
Preparation of 2–5. a) pentafluorophenol, 1,3-diisopropylcarbodiimide, CH2Cl2; b) 2-phenylethylamine, 4-aminobutyric acid, or methylamine hydrochloride, iPr2EtN, DMF, 49% (13a), 70% (13b), or 68% (13c) yield for two steps; c) Ac2O, pyridine, then (for 4 and 6) H2O/dioxane, 99% (3), 81% (4), 90% (5), or 97% (6).
Preparation of 2–5. a) pentafluorophenol, 1,3-diisopropylcarbodiimide, CH2Cl2; b) 2-phenylethylamine, 4-aminobutyric acid, or methylamine hydrochloride, iPr2EtN, DMF, 49% (13a), 70% (13b), or 68% (13c) yield for two steps; c) Ac2O, pyridine, then (for 4 and 6) H2O/dioxane, 99% (3), 81% (4), 90% (5), or 97% (6).
Bromoethene
CAS number: 593-60-2
Bromoethane is a bromoalkane that is ethane carrying a bromo substituent.
Highly Z-selective olefination. [a] Vinyl bromide (1.05 equiv), tBuLi (2.1 equiv), THF, À788C; then boronic ester (1.0 equiv), THF, À788C; then PhSeCl (1.2 equiv), THF, À788C to RT; then NaOMe (5.0–20.0 equiv), THF/MeOH (1:1), 08C or RT. [b] PhSe- SePh removed by oxidation with H2O2. [c] Ate complex formed with 16 and MeLi (1.05 equiv).
Highly Z-selective olefination. [a] Vinyl bromide (1.05 equiv), tBuLi (2.1 equiv), THF, À788C; then boronic ester (1.0 equiv), THF, À788C; then PhSeCl (1.2 equiv), THF, À788C to RT; then NaOMe (5.0–20.0 equiv), THF/MeOH (1:1), 08C or RT. [b] PhSe- SePh removed by oxidation with H2O2. [c] Ate complex formed with 16 and MeLi (1.05 equiv).