Chemicals list & Research Gallery
CAS number: 108-30-5
Succinic anhydride is a cyclic dicarboxylic anhydride and a tetrahydrofurandione. It is functionally related to a succinic acid.
Synthetic route for the preparation of 4a−e from cisplatin: (a) 30% H2O2, 50 °C; (b) succinic anhydride, anhydrous DMSO, room temperature; (c) R−N=C=O, anhydrous DMF, room temperature
CAS number: 108-46-3
Resorcinol is a benzenediol that is benzene dihydroxylated at positions 1 and 3. It has a role as an erythropoietin inhibitor and a sensitiser. It is a benzenediol, a member of resorcinols and a phenolic donor.
General scheme for the reaction of aldehydes with alkylated resorcinols.
CAS number: 108-48-5
2,6-dimethylpyridine is a member of the class of methylpyridines that is pyridine carrying methyl substituents at positions 2 and 6. It derives from a hydride of a pyridine.
Synthesis of fully protected trinucleotides
CAS number: 108-75-8
2,4,6-Trimethylpyridine, also known as collidine, belongs to the class of organic compounds known as methylpyridines.
Reagents and conditions: i, Ph3CCl, Et3N, CH2Cl2, 92%; ii, LiCMCCH2OTBS (3), THF, BF3?OEt2, 278 uC, 93%; iii, TBSCl, imidazole, DMF; iv, TBAF, THF, 80% from 2; v, Red-Al, Et2O; vi, MsCl, LiCl, collidine, DMF, 0 uC A rt, 83% from 4; vii, LiSnBu3, THF, 278 uC, 93%; viii, TBAF, THF, 79%; ix, Tf2O, collidine, CH2Cl2, Et3N, 288 uC, 99%.
Reagents and conditions: i, BH3?SMe2, NaBH4 (cat), THF, 88%;ii, Ph3CCl, Et3N, CH2Cl2, 64%; iii, TBSCl, imidazole, DMF, 92%; iv,DIBALH, CH2Cl2, 0 uC, 94%; v, TPAP (cat), NMO, 4 A mol. sieves,CH2Cl2, 78%; vi, (CF3CH2O)2P(O)CH2CO2Me (11), KHMDS, 18-crown-6, THF, 89%; vii, DIBALH, CH2Cl2, 0 uC, 76%; viii, MsCl, LiCl, collidine,DMF, 0 uC A rt, 99%; ix, LiSnBu3, THF, 278 uC, 93%; x, TBAF, THF,collidine, 0 uC A rt, 63%; xi, Tf2O, collidine, CH2Cl2, Et3N, 278 uC, 91%.
Reagents and conditions: i, LiAlH4, THF; Bu3SnOTf, 0 uC A rt, 83%; ii, 5, PdCl2(MeCN)2, NMP; iii, MsCl, LiCl, collidine, DMF, 0 uC A rt; iv, LiSnBu3, THF, 278 uC, 78% from 15; v, TBAF, THF, Et3N, 72%; vi, Tf2O, collidine, CH2Cl2, Et3N, 278 uC, 99%.
CAS number: 108-86-1
Bromobenzene is the simplest member of the class of bromobenzenes, that is benzene in which a single hydrogen has been substituted by a bromine. A liquid at room temperature (m.p. -30℃; b.p.760 156℃), it is used as a solvent, particularly for large-scale crystallisations, and for the introduction of phenyl groups in organic synthesis. It has a role as a non-polar solvent, a hepatotoxic agent and a mouse metabolite. It is a member of bromobenzenes, a bromoarene and a volatile organic compound.
Synthesis of homochiral azide 5 from bromobenzene.
Reaction rate in the Mizoroki-Heck reaction of bromobenzene with n-butyl acrylate using 6 as precatalyst and adding mercury after 4 h.
CAS number: 108-87-2
Methylcyclohexane is a cycloalkane that is cyclohexane substituted by a single methyl group. It has a role as an aprotic solvent, a plant metabolite and a human metabolite. It is a cycloalkane and a volatile organic compound. It derives from a hydride of a cyclohexane.
Fluorescence spectra of 1,3-diphenylpropenes t-1-t-4 in methylcyclohexane at room temperature.
CAS number: 108-90-7
Chlorobenzene is a colorless, flammable liquid with an aromatic, almond-like odor. Some of it will dissolve in water, but it readily evaporates into air. It does not occur naturally in the environment. Chlorobenzene production in the United States has declined by more than 60% from its peak in 1960. It was used in the past to make other chemicals, such as phenol and DDT. Now chlorobenzene is used as a solvent for some pesticide formulations, to degrease automobile parts, and as a chemical intermediate to make several other chemicals.
Oxygen consumption measured during autoxidation experiments in chlorobenzene initiated by AIBN (0.05m) at 308C with the following reactants: a) styrene (2.1m); b) CHD (cyclohexadiene, 0.26m); c) styrene (2.1m) and TOH (5 mm); d) CHD (0.26m) and TOH (6.2 mm).
Peroxidation traces (linoleic acid hydroperoxide concentration vs time) recorded using compound 16a (40 μM) or R-TOH (40 μM) as antioxidants in the chlorobenzene layer in the presence of NAC (1 mM) in the aqueous phase.
CAS number: 108-94-1
Cyclohexanone is a cyclic ketone that consists of cyclohexane bearing a single oxo substituent. It has a role as a human xenobiotic metabolite.
Arylation and vinylation of cyclohexanone using ligand L1.
CAS number: 108-95-2
Phenol, liquid appears as a colorless liquid when pure, otherwise pink or red. Combustible. Flash point 175 °F. Must be heated before ignition may occur easily. Vapors are heavier than air. Corrosive to skin but because of anesthetic qualities will numb rather than burn. Upon contact skin may turn white. May be lethal by skin absorption. Does not react with water. Stable in normal transportation. Reactive with various chemicals and may be corrosive to lead, aluminum and its alloys, certain plastics, and rubber. Freezing point about 105 °F. Density 8.9 lb / gal. Used to make plastics, adhesives and other chemicals.
Alkylation of Phenol 6
CAS number: 1083168-84-6
2-Methoxy-5-methylpyridine-3-boronic acid pinacol ester, also known as 2-Methoxy-5-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine pinacol ester, is an organoboron compound featuring a pyridine ring substituted with a methoxy group at the 2-position, a methyl group at the 5-position, and a boronic ester moiety at the 3-position.
Aryl and vinyl chlorides were cross-coupled with aryl and vinyl boronic acids, pinacol esters, and potassium trifluoroborate under nonbasic conditions mediated by 11. Yields are from isolated chromatographically homogeneous material (average of two runs) and were not optimized for time and catalyst loading.