Chemicals list & Research Gallery

(1E,2E)-1,2-Ethanedione 1,2-dioxime
CAS number: 522-34-9
(1E,2E)-1,2-Ethanedione 1,2-dioxime, also known as diacetyl dioxime or dimethylglyoxime. Structurally, it consists of a central ethane backbone bearing two oxime groups (=C=NOH) at each carbon of the diketone moiety, with both oxime bonds in the E (trans) configuration. It typically appears as a pale yellow crystalline solid that is sparingly soluble in water but soluble in alcohols and organic solvents. It is best known for its ability to selectively form bright red chelate complexes with nickel(II) ions, making it a widely used analytical reagent in gravimetric and qualitative analysis of nickel. Its chelating properties stem from the two oxime nitrogen atoms, which coordinate tightly to metal centers.
Synthesis of oxadiazole from benzil dioxime.
Synthesis of oxadiazole from benzil dioxime.
9,10-Dibromoanthracene
CAS number: 523-27-3
9,10-Dibromoanthracene is an organic chemical compound containing anthracene with two bromine atoms substituted on its central ring.
The formation of diarylanthracene 3 from 9,10-dibromoanthracene (1) and boronic acid 2 was planned.
The formation of diarylanthracene 3 from 9,10-dibromoanthracene (1) and boronic acid 2 was planned.
Kinetin
CAS number: 525-79-1
Kinetin is a cytokinin, or adenine derivative, found in various plants and human cells.
The Influence of hydroxy or methoxy group position in the benzyl ring of 6-benzyl-9-tetrahydropyran-2-yl-purines on their biological activity in classical cytokinin bioassays. Comparison of the impact of hydroxy (A–C) and methoxy (D–F) groups substituted in ortho- (circles), meta- (triangles), and para- (diamonds) positions, respectively, on: the retention of chlorophyll in excised wheat leaves (A, D); the stimulation of cytokinin-dependent tobacco callus growth (B, E); and the dark induction of betacyanin synthesis in Amaranthus cotyledons (C, F).
The Influence of hydroxy or methoxy group position in the benzyl ring of 6-benzyl-9-tetrahydropyran-2-yl-purines on their biological activity in classical cytokinin bioassays. Comparison of the impact of hydroxy (A–C) and methoxy (D–F) groups substituted in ortho- (circles), meta- (triangles), and para- (diamonds) positions, respectively, on: the retention of chlorophyll in excised wheat leaves (A, D); the stimulation of cytokinin-dependent tobacco callus growth (B, E); and the dark induction of betacyanin synthesis in Amaranthus cotyledons (C, F).
The Influence of 9-tetrahydropyran-2-yl and 9-tetrahydrofuran-2-yl groups on the biological activity of 6-benzyl-(3-hydroxybenzylamino)purine in classical cytokinin bioassays. (A) The effect on chlorophyll retention in excised wheat leaf tips; (B) the growth of cytokinin-dependent tobacco callus; (C) the effect on dark betacyanin synthesis in Amaranthus caudatus cotyledon-hypocotyl explants.
The Influence of 9-tetrahydropyran-2-yl and 9-tetrahydrofuran-2-yl groups on the biological activity of 6-benzyl-(3-hydroxybenzylamino)purine in classical cytokinin bioassays. (A) The effect on chlorophyll retention in excised wheat leaf tips; (B) the growth of cytokinin-dependent tobacco callus; (C) the effect on dark betacyanin synthesis in Amaranthus caudatus cotyledon-hypocotyl explants.
2-Methylbenzamide
CAS number: 527-85-5
2-METHYLBENZAMIDE is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. 2-Methylbenzamide (o-Toluamide) has been used in total synthesis of phenolic protoberberine alkaloid, cerasonine.
Synthesis of Toluamide 3
Synthesis of Toluamide 3
Tropane
CAS number: 529-17-9
Tropane is a bicyclic amine with pyrrolidine and piperidine rings, found as esters in plants, and is a precursor to many pharmaceuticals.
Chemical structures of cocaine and other tropane-based DAT inhibitors.
Chemical structures of cocaine and other tropane-based DAT inhibitors.
Representative natural products and biological active compounds with tropane frameworks. Boc=tert-butoxycarbonyl.
Representative natural products and biological active compounds with tropane frameworks. Boc=tert-butoxycarbonyl.
a) A reported strategy and b) our strategy for the construction of functionalized tropane derivatives.
a) A reported strategy and b) our strategy for the construction of functionalized tropane derivatives.
2-Aminobenzaldehyde
CAS number: 529-23-7
2-Aminobenzaldehyde is one of three isomers of aminobenzaldehyde. It is a low-melting yellow solid that is soluble in water.
Reagents and conditions: (a) LHMDS, THF, -78 °C to rt, 20%; (b) 2-aminonicotinaldehyde or 2-aminobenzaldehyde, KOH, EtOH, reflux, 47%. (c) ethylsulfonylethene, TEA, MeOH, reflux; (d) 4-fluoro-3-trifluoromethylphenylacetic acid, EDC, HOBt, NMM, DMF, rt, 80–90% two steps. (e) Pd(PPh3)4, CuI, NaCN, MeCN, microwave, 120 °C, 80–90%. Enantiomerically pure products were isolated by chiral phase HPLC.
Reagents and conditions: (a) LHMDS, THF, -78 °C to rt, 20%; (b) 2-aminonicotinaldehyde or 2-aminobenzaldehyde, KOH, EtOH, reflux, 47%. (c) ethylsulfonylethene, TEA, MeOH, reflux; (d) 4-fluoro-3-trifluoromethylphenylacetic acid, EDC, HOBt, NMM, DMF, rt, 80–90% two steps. (e) Pd(PPh3)4, CuI, NaCN, MeCN, microwave, 120 °C, 80–90%. Enantiomerically pure products were isolated by chiral phase HPLC.
Nisoxetine
CAS number: 53179-07-0
Nisoxetine was first developed by Eli Lilly as a non-tricyclic antidepressant drug.
Structures of fluoxetine, atomoxetine, and nisoxetine.
Structures of fluoxetine, atomoxetine, and nisoxetine.
Examples of monoamine reuptake inhibitors containing a 3-aryl-3-phenoxypropylamine motif: fluoxetine, nisoxetine, atomoxetine
Examples of monoamine reuptake inhibitors containing a 3-aryl-3-phenoxypropylamine motif: fluoxetine, nisoxetine, atomoxetine
Phenylacetylene
CAS number: 536-74-3
Phenylacetylene (also known as Ethynylbenzene) is an alkyne hydrocarbon bonded to a benzene ring. It is an aromatic organic compound frequently employed in Sonogashira coupling reactions.
Recycling of catalyst for the reaction of iodobenzene with phenylacetylene.
Recycling of catalyst for the reaction of iodobenzene with phenylacetylene.
Coupling of liquid iodoarenes with phenylacetylene in water.
Coupling of liquid iodoarenes with phenylacetylene in water.
Pd-catalyzed cyanation of phenylacetylene with TMSCN.
Pd-catalyzed cyanation of phenylacetylene with TMSCN.
Reaction profiles for phenylacetylene/o-fluoranil cycloadditions, calculated at the B3LYP/6-31G/ level of theory.
Reaction profiles for phenylacetylene/o-fluoranil cycloadditions, calculated at the B3LYP/6-31G/ level of theory.
Transition states for reactions of phenylacetylene with o-fluoranil.
Transition states for reactions of phenylacetylene with o-fluoranil.
Dicyclohexylcarbodiimide
CAS number: 538-75-0
DCC (dicyclohexyl carbodiimide) is one of the most frequently used coupling agents, especially in organic synthesis applications.
Attempted amino acid coupling: glycine ethyl ester, N,N'-dicyclohexyl carbodiimide (DCCI) or 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDAC), 1-hydroxybenzotriazole (HOBt), water, room temperature.
Attempted amino acid coupling: glycine ethyl ester, N,N'-dicyclohexyl carbodiimide (DCCI) or 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDAC), 1-hydroxybenzotriazole (HOBt), water, room temperature.
Synthesis of the BC ring system. DCC=dicyclohexylcarbo-diimide, DMAP=4-dimethylaminopyridine, DIBALH=diisobutylaluminum hydride, R=o-tolyl.
Synthesis of the BC ring system. DCC=dicyclohexylcarbo-diimide, DMAP=4-dimethylaminopyridine, DIBALH=diisobutylaluminum hydride, R=o-tolyl.
Ethyl chloroformate
CAS number: 541-41-3
Ethyl chloroformate appears as a colorless liquid with a pungent odor. Flash point 66 °F. Very toxic by inhalation. Corrosive to metals and tissue.
Introduction of ester group with ethyl chloroformate.
Introduction of ester group with ethyl chloroformate.