Chemicals list & Research Gallery

4-Morpholinecarbonyl chloride
CAS number: 15159-40-7
4-Morpholinecarbonyl chloride may be used in the preparation of a versatile fluorogenic label for biomolecular imaging. It may be used in the synthesis of: morpholine-4-carboxylic acid [4-(2,4-dimethylphenyl)thiazol-2-yl]amide.
Reagents and conditions: (a) 2-methoxbenzoyl chloride, DIEA, DCE, room temperature; (b) 2,4-dichlorobenzoyl chloride, DIEA, DCE, room tempera- ture; (c) 4-morpholinecarbonyl chloride, DIEA, DCE, room temperature; (d) phenylsulfonyl chloride, DIEA, DCE, room temperature.
Reagents and conditions: (a) 2-methoxbenzoyl chloride, DIEA, DCE, room temperature; (b) 2,4-dichlorobenzoyl chloride, DIEA, DCE, room tempera- ture; (c) 4-morpholinecarbonyl chloride, DIEA, DCE, room temperature; (d) phenylsulfonyl chloride, DIEA, DCE, room temperature.
Aplyronine A
CAS number: 151923-84-1
Aplyronine A is a macrolide isolated from Aplysia kurodai. By monitoring fluorescent intensity of pyrenyl-actin, it was found that aplyronine A inhibited both the velocity and the degree of actin polymerization. Aplyronine A also quickly depolymerized F-actin.
Aplyronine A: mixture of four side chain diastereomers.
Aplyronine A: mixture of four side chain diastereomers.
Agelastatin A
CAS number: 152406-28-5
Agelastatin A is a marine alkaloid with potent biological activity.
Structures of (−)-agelastatins A−F (1−6).
Structures of (−)-agelastatins A−F (1−6).
Early Approach toward (−)-Agelastatin A (1)
Early Approach toward (−)-Agelastatin A (1)
Retrobiosynthetic Analysis of (−)-Agelastatin A (1)
Retrobiosynthetic Analysis of (−)-Agelastatin A (1)
Our First-Generation Total Synthesis of ( )-Agelastatin A (1)
Our First-Generation Total Synthesis of ( )-Agelastatin A (1)
Imatinib
CAS number: 152459-95-5
Imatinib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein in cancer cells.
(Left) Interaction of STI-571 and (right) 11b from MCPRO+ calculations. Only nearby residues and water with H-bonding interactions with the ligand are shown. Images were created with PYMOL v1.5.0.4
(Left) Interaction of STI-571 and (right) 11b from MCPRO+ calculations. Only nearby residues and water with H-bonding interactions with the ligand are shown. Images were created with PYMOL v1.5.0.4
Thioguanine
CAS number: 154-42-7
Thioguanine (also referred to as 6-thioguanine and as tioguanine) is a purine analogue that is used in the therapy of acute and chronic myelogenous leukemias.
Structures of 6-mercaptopurine and thioguanine and their 5-aza-7-deaza analogs.
Structures of 6-mercaptopurine and thioguanine and their 5-aza-7-deaza analogs.
Potassium ascorbate
CAS number: 15421-15-5
Potassium Ascorbate is a form of Vitamin C that is water-soluble and can be taken internally.
Synthesis of nucleoside borane conjugates by “chemical ligation” of nucleoside borane acceptors and borane donors: 17–24. i) 2, 5, or 6, CuSO4·5H2O/potassium ascorbate, tert-butyl alcohol/water 1:1; ii) 7 or 8, CuSO4·5H2O/potassium ascorbate, tert-butyl alcohol/water 1:1
Synthesis of nucleoside borane conjugates by “chemical ligation” of nucleoside borane acceptors and borane donors: 17–24. i) 2, 5, or 6, CuSO4·5H2O/potassium ascorbate, tert-butyl alcohol/water 1:1; ii) 7 or 8, CuSO4·5H2O/potassium ascorbate, tert-butyl alcohol/water 1:1
Dichlorocarbene
CAS number: 1605-72-7
Dichlorocarbene is a chemical compound that is formed when chloroform reacts with a base.
Voltammograms of reference molecular subunits 7-10 and multicomponent systems 1-4 were measured in CH2Cl2 with 0.1 mol/L▔1 nBu4NClO4 (TBAP) as supporting electrolyte. Scan rate: 0.2 Vs▔1
Voltammograms of reference molecular subunits 7-10 and multicomponent systems 1-4 were measured in CH2Cl2 with 0.1 mol/L▔1 nBu4NClO4 (TBAP) as supporting electrolyte. Scan rate: 0.2 Vs▔1
The ladder-like chain structure of the complex 2. The copper atoms are displayed as octahedrons, hexfluoroacetylacetone, hydrogen atoms and the disordered dichloromethane are omitted for clarity.
The ladder-like chain structure of the complex 2. The copper atoms are displayed as octahedrons, hexfluoroacetylacetone, hydrogen atoms and the disordered dichloromethane are omitted for clarity.
Bridge splitting of 1 with MeOH (a), MeCN (b) and cyclooctene (c) in dichloromethane at various temperatures.
Bridge splitting of 1 with MeOH (a), MeCN (b) and cyclooctene (c) in dichloromethane at various temperatures.
Eyring plots for bridge splitting of 1 with MeOH, MeCN and cyclooctene in dichloromethane.
Eyring plots for bridge splitting of 1 with MeOH, MeCN and cyclooctene in dichloromethane.
2-Cyclopropen-1-ylidene
CAS number: 16165-40-5
2-Cyclopropen-1-ylidene, also known as cyclopropenylidene, is a highly reactive and unstable carbene. It consists of a three-membered cyclopropene ring with a divalent carbon atom (a carbene) replacing one of the ring's hydrogen atoms, resulting in a structure featuring both ring strain and a reactive lone pair.
Cyclopropenes can be selectively detected on model proteins.
Cyclopropenes can be selectively detected on model proteins.
2-phenyl-2,3-dihydroquinolin-4(1H)-one
CAS number: 16619-14-0
2-phenyl-2,3-dihydroquinolin-4(1H)-one is a chemical compound, specifically a dihydroquinoline derivative. It is also known as 2,3-Dihydro-2-phenyl-4(1H)-quinolinone or azaflavanone.
Synthesis of 2-phenyl-2,3-dihydroquinolin-4(1H)-one (2) from 2'-aminochalcone (1).
Synthesis of 2-phenyl-2,3-dihydroquinolin-4(1H)-one (2) from 2'-aminochalcone (1).
Kinetics curves of the yield to 2-phenyl-2,3-dihydroquinolin-4(1H)-one obtained with different solid acid catalysts (8 wt%) starting from 2'-Aminochalcone (1 mmol) in toluene (0.5 mL) at 1008C. MCM-41 (■), ITQ-2 (●), HBeta (▲), USY (◆), 15 wt% Mordenite (x), 15 wt% Sn-MCM-41(+).
Kinetics curves of the yield to 2-phenyl-2,3-dihydroquinolin-4(1H)-one obtained with different solid acid catalysts (8 wt%) starting from 2'-Aminochalcone (1 mmol) in toluene (0.5 mL) at 1008C. MCM-41 (■), ITQ-2 (●), HBeta (▲), USY (◆), 15 wt% Mordenite (x), 15 wt% Sn-MCM-41(+).
Yield of 2-phenyl-2,3-dihydroquinolin-4(1H)-one (2) versus time obtained for HBeta (▲) and Betanano (■) using 2'-aminochalcone (1 mmol) in toluene (0.5 mL) at 1008C.
Yield of 2-phenyl-2,3-dihydroquinolin-4(1H)-one (2) versus time obtained for HBeta (▲) and Betanano (■) using 2'-aminochalcone (1 mmol) in toluene (0.5 mL) at 1008C.
Yield of 2-phenyl-2,3-dihydroquinolin-4(1H)-one (2) versus time when the aza-Michael addition was performed using MCM-41 with different Si/Al ratios. Si/Al=15 (■), 30 (●), 50 (▲), Si-MCM-41 (◆). Reaction conditions: 2;-aminochalcone (1 mmol), MCM-41 (8 wt%), at 1008C, in toluene (0.5 mL).
Yield of 2-phenyl-2,3-dihydroquinolin-4(1H)-one (2) versus time when the aza-Michael addition was performed using MCM-41 with different Si/Al ratios. Si/Al=15 (■), 30 (●), 50 (▲), Si-MCM-41 (◆). Reaction conditions: 2;-aminochalcone (1 mmol), MCM-41 (8 wt%), at 1008C, in toluene (0.5 mL).
Dichloromethane-d2
CAS number: 1665-00-5
Dichloromethane-d2, also known as methylene chloride-d2 or dideuteromethylenechloride, is a deuterated form of the solvent dichloromethane (CH2Cl2).
Zoom-in of the nitroxyl protons in the 1H NMR spectrum of 3a (CD2Cl2, 400 MHz, 20 °C).
Zoom-in of the nitroxyl protons in the 1H NMR spectrum of 3a (CD2Cl2, 400 MHz, 20 °C).
1H NMR spectra of (i) 1, (ii) the mixture of GaCl3 and 1, and (iii) the mixture of InBr3 and 1 in CD2Cl2.
1H NMR spectra of (i) 1, (ii) the mixture of GaCl3 and 1, and (iii) the mixture of InBr3 and 1 in CD2Cl2.
Section of the 1H-NOESY NMR spectrum of complex 1d recorded at 400.13 MHz in methylene chloride-d2 (298 K) showing the selective intramolecular interactions of the hydrides with protons H-6 and H-o.
Section of the 1H-NOESY NMR spectrum of complex 1d recorded at 400.13 MHz in methylene chloride-d2 (298 K) showing the selective intramolecular interactions of the hydrides with protons H-6 and H-o.