Chemicals list & Research Gallery

Fatty acids
CAS number: 67254-79-9
Fatty acids, one class of essential nutrients for humans, are an important source of energy and an essential component of cell membranes. Most fatty acids in plants and animals have an even carbon number and no branching. One or more double bonds may occur, mostly in cis configuration. More than 40 different fatty acids are commonly encountered in foods.
N-Substituted pantothenamides (such as N-pentyl pan- tothenamide shown above) act as antimetabolites by forming coenzyme A analogues which do not contain the essential terminal thiol group of natural CoA. These analogues subsequently transfer inactive prosthetic groups to the acyl carrier proteins that are involved in fatty acid metabolism, thereby blocking these processes.
N-Substituted pantothenamides (such as N-pentyl pan- tothenamide shown above) act as antimetabolites by forming coenzyme A analogues which do not contain the essential terminal thiol group of natural CoA. These analogues subsequently transfer inactive prosthetic groups to the acyl carrier proteins that are involved in fatty acid metabolism, thereby blocking these processes.
Dipyrone
CAS number: 68-89-3
Dipyrone, also known as metamizole, is a pain reliever (analgesic) and fever reducer (antipyretic) that is used to treat moderate to severe pain and fever. It is available in various forms like oral tablets, suppositories, and injections. While widely used in many countries, it has been banned or restricted in some, including the United States, due to concerns about potentially serious side effects like agranulocytosis (a severe reduction in white blood cells).
Metabolites of dipyrone (1).
Metabolites of dipyrone (1).
Concentrations of 5 (A) and 6 (B) in the brain of wild-type mice (FAAH+/+) and of FAAH knockout mice (FAAHÀ/À) after administration of dipyrone or water for five days (n = 3 mice/group, mean SEM).
Concentrations of 5 (A) and 6 (B) in the brain of wild-type mice (FAAH+/+) and of FAAH knockout mice (FAAHÀ/À) after administration of dipyrone or water for five days (n = 3 mice/group, mean SEM).
Burkholderia cepacia
CAS number: 68332-96-7
Burkholderia cepacia is a plant phytogen and is known as a hardy and versatile organism.
EMDee assay of allylic acetate 2 using the lipase from Pseudomonas cepacia.
EMDee assay of allylic acetate 2 using the lipase from Pseudomonas cepacia.
Plot of the rate of the lipase-catalyzed reaction as a function of the concentration of (R)-2.
Plot of the rate of the lipase-catalyzed reaction as a function of the concentration of (R)-2.
Analysis of 88 samples of compound 2 that range in ee from 100% (S) to 100% (R) using the lipase from Pseudomonas cepacia.
Analysis of 88 samples of compound 2 that range in ee from 100% (S) to 100% (R) using the lipase from Pseudomonas cepacia.
Structures of several substrates for the lipase from Pseudomonas cepacia.
Structures of several substrates for the lipase from Pseudomonas cepacia.
Pseudomonas syringae, strain ESC-10
CAS number: 68583-32-4
Pseudomonas syringae strain ESC-10 is a naturally occurring bacterium, originally isolated from apples, that is used as a biological control agent to prevent fungal diseases on fruits.
In vitro growth of Pseudomonas syringae (Pst) in the presence of dihydrocarbazine acid (DHCA), carbazine acid, or DHCA analogs
In vitro growth of Pseudomonas syringae (Pst) in the presence of dihydrocarbazine acid (DHCA), carbazine acid, or DHCA analogs
Effects of dihydrocarbamazepine (DHCA) and salicylic acid (SA) on biofilm formation of Pseudomonas syringae (Pst) in vitro
Effects of dihydrocarbamazepine (DHCA) and salicylic acid (SA) on biofilm formation of Pseudomonas syringae (Pst) in vitro
Exogenous infiltration of dihydroindole acid (DHCA) and bacterial quantification of P. syringae in 7-week-old Col-0 and cyp71a12/cyp71a13 rosette leaves.
Exogenous infiltration of dihydroindole acid (DHCA) and bacterial quantification of P. syringae in 7-week-old Col-0 and cyp71a12/cyp71a13 rosette leaves.
Salicylic acid
CAS number: 69-72-7
Salicylic acid is a beta hydroxy acid (BHA) primarily known for its use in skincare, particularly for treating acne and other skin conditions.
Effects of dihydrocarbamazepine (DHCA) and salicylic acid (SA) on biofilm formation of Pseudomonas syringae (Pst) in vitro
Effects of dihydrocarbamazepine (DHCA) and salicylic acid (SA) on biofilm formation of Pseudomonas syringae (Pst) in vitro
Diisopropylcarbodiimide
CAS number: 693-13-0
Diisopropylcarbodiimide has been used in industry as a stabilizing agent, coupling agent, and condensing agent. The potential for exposure exists during the synthesis of polypeptides and other chemicals in the chemical and pharmaceutical industries, as well as during protein synthesis in the recombinant DNA industry.
Preparation of 2–5. a) pentafluorophenol, 1,3-diisopropylcarbodiimide, CH2Cl2; b) 2-phenylethylamine, 4-aminobutyric acid, or methylamine hydrochloride, iPr2EtN, DMF, 49% (13a), 70% (13b), or 68% (13c) yield for two steps; c) Ac2O, pyridine, then (for 4 and 6) H2O/dioxane, 99% (3), 81% (4), 90% (5), or 97% (6).
Preparation of 2–5. a) pentafluorophenol, 1,3-diisopropylcarbodiimide, CH2Cl2; b) 2-phenylethylamine, 4-aminobutyric acid, or methylamine hydrochloride, iPr2EtN, DMF, 49% (13a), 70% (13b), or 68% (13c) yield for two steps; c) Ac2O, pyridine, then (for 4 and 6) H2O/dioxane, 99% (3), 81% (4), 90% (5), or 97% (6).
Diisopropylethylamine
CAS number: 7087-68-5
N,N-Diisopropylethylamine (DIPEA) is a tertiary amino compound. It is a colorless liquid and is also known as Hunig's base.
Preparation of alkene 14 (DIPEA = N,N-diisopropyl-ethylamine).
Preparation of alkene 14 (DIPEA = N,N-diisopropyl-ethylamine).
Peptoid-synthesis-inspired modular assembly of azaxylylene precursors and their cyclizations. [a] Acetal hydrolysis step is required only in the a (i.e. benzaldehyde) series. [b] Major diastereomer is shown, the minor hydroxy epimer (not shown) is denoted with a prime, 16’a etc. Bn=benzyl, DIPEA=diisopropylethylamine, PTS=pyridinium para-tolue-nesulfonate.
Peptoid-synthesis-inspired modular assembly of azaxylylene precursors and their cyclizations. [a] Acetal hydrolysis step is required only in the a (i.e. benzaldehyde) series. [b] Major diastereomer is shown, the minor hydroxy epimer (not shown) is denoted with a prime, 16’a etc. Bn=benzyl, DIPEA=diisopropylethylamine, PTS=pyridinium para-tolue-nesulfonate.
Synthesis of triazine dimers 1–47. Reagents and conditions: (a) diaminoalkanes/diaminobenzene/piperazine, DIPEA, dry dioxane, 110 °C.
Synthesis of triazine dimers 1–47. Reagents and conditions: (a) diaminoalkanes/diaminobenzene/piperazine, DIPEA, dry dioxane, 110 °C.
Synthesis of β-LEAP. DIPEA=N,N’-diisopropylethylamine, NMM=4-methylmorpholine, HATU=O-(7-azabenzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate, TEA=triethylamine, TFA=trifluoroacetic acid.
Synthesis of β-LEAP. DIPEA=N,N’-diisopropylethylamine, NMM=4-methylmorpholine, HATU=O-(7-azabenzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate, TEA=triethylamine, TFA=trifluoroacetic acid.
Sulfuryl diazide
CAS number: 72250-07-8
Sulfuryl diazide is a chemical compound that consists of a sulfur atom bonded to two oxygen atoms and two nitrogen atoms, forming a unique molecular structure.
Copper(I)-Catalyzed Reaction of 1-(Cyclopropylidenemethyl)-2-ethynylheteroarene 1 with Sulfonyl Azide 2
Copper(I)-Catalyzed Reaction of 1-(Cyclopropylidenemethyl)-2-ethynylheteroarene 1 with Sulfonyl Azide 2
L-Arginine
CAS number: 74-79-3
L-arginine is an amino acid that helps build protein and acts as a vasodilator, opening blood vessels. It is generally safe.
(a) HPLC spectrum of crude arginine 3 after solid phase assembly and two-step deprotection. Conditions: Same as Figure 3. (b) HPLC spectrum of arginine 3 after single-step final purification. Conditions: Same as Figure 3.
(a) HPLC spectrum of crude arginine 3 after solid phase assembly and two-step deprotection. Conditions: Same as Figure 3. (b) HPLC spectrum of arginine 3 after single-step final purification. Conditions: Same as Figure 3.
(a) Compounds investigated in this study. Byproducts in the synthesis of 3. Intermediates in the synthesis of 3. (b) X-ray structure of arginine 3 in complex with Af ChiB1, showing the key residues for SAR formation (model extracted from previously published complex 22a, PDB entry 1W9V).
(a) Compounds investigated in this study. Byproducts in the synthesis of 3. Intermediates in the synthesis of 3. (b) X-ray structure of arginine 3 in complex with Af ChiB1, showing the key residues for SAR formation (model extracted from previously published complex 22a, PDB entry 1W9V).
When the nucleotides were neutralized to pH 7.0 with NaOH or basic amino acids (L-lysine, L-arginine, or L-histidine), the reaction rate was significantly accelerated and the yield was comparable to that of porcine pancreatic lipase (PPL, one of the best enzymes for the Knoevenagel condensation reaction) as well as pH-neutral amino acid salts Arg•HCl and Lys•HCl.
When the nucleotides were neutralized to pH 7.0 with NaOH or basic amino acids (L-lysine, L-arginine, or L-histidine), the reaction rate was significantly accelerated and the yield was comparable to that of porcine pancreatic lipase (PPL, one of the best enzymes for the Knoevenagel condensation reaction) as well as pH-neutral amino acid salts Arg•HCl and Lys•HCl.
Pyrraline
CAS number: 74509-14-1
Pyrraline, also known as 2-FHMPN, belongs to the class of organic compounds known as alpha amino acids. It is derived from 3-deoxyglucosone, can be released from proteins by acid or enzymatic hydrolysis.
Chemical structures of the investigated Maillard reaction prod- ucts fructoselysine (1), lactuloselysine (2), tagatoselysine (3), CML (4), CEL (5), formyline (6), pyrraline (7), maltosine (8), MG-H1 (9), argpyrimidine (10), and pentosidine (11).
Chemical structures of the investigated Maillard reaction prod- ucts fructoselysine (1), lactuloselysine (2), tagatoselysine (3), CML (4), CEL (5), formyline (6), pyrraline (7), maltosine (8), MG-H1 (9), argpyrimidine (10), and pentosidine (11).