Chemicals list & Research Gallery

9,10-Dibromoanthracene
CAS number: 523-27-3
9,10-Dibromoanthracene is an organic chemical compound containing anthracene with two bromine atoms substituted on its central ring.
The formation of diarylanthracene 3 from 9,10-dibromoanthracene (1) and boronic acid 2 was planned.
The formation of diarylanthracene 3 from 9,10-dibromoanthracene (1) and boronic acid 2 was planned.
Malonyl CoA
CAS number: 524-14-1
Malonyl-CoA is the S-malonyl derivative of coenzyme A. It has a role as an EC 2.3.1.21 (carnitine O-palmitoyltransferase) inhibitor, a metabolite, an Escherichia coli metabolite and a mouse metabolite. It is functionally related to a coenzyme A. It is a conjugate acid of a malonyl-CoA(5-).
Postulated mechanism of plumbagin biosynthesis and comparison with the reaction of chalcone synthase (CHS). The PKS involved in plumbagin (8) biosynthesis presumably catalyzes the decarboxylative condensation of acetyl-CoA (5) with five molecules of malonyl-CoA (1).
Postulated mechanism of plumbagin biosynthesis and comparison with the reaction of chalcone synthase (CHS). The PKS involved in plumbagin (8) biosynthesis presumably catalyzes the decarboxylative condensation of acetyl-CoA (5) with five molecules of malonyl-CoA (1).
Kinetin
CAS number: 525-79-1
Kinetin is a cytokinin, or adenine derivative, found in various plants and human cells.
The Influence of hydroxy or methoxy group position in the benzyl ring of 6-benzyl-9-tetrahydropyran-2-yl-purines on their biological activity in classical cytokinin bioassays. Comparison of the impact of hydroxy (A–C) and methoxy (D–F) groups substituted in ortho- (circles), meta- (triangles), and para- (diamonds) positions, respectively, on: the retention of chlorophyll in excised wheat leaves (A, D); the stimulation of cytokinin-dependent tobacco callus growth (B, E); and the dark induction of betacyanin synthesis in Amaranthus cotyledons (C, F).
The Influence of hydroxy or methoxy group position in the benzyl ring of 6-benzyl-9-tetrahydropyran-2-yl-purines on their biological activity in classical cytokinin bioassays. Comparison of the impact of hydroxy (A–C) and methoxy (D–F) groups substituted in ortho- (circles), meta- (triangles), and para- (diamonds) positions, respectively, on: the retention of chlorophyll in excised wheat leaves (A, D); the stimulation of cytokinin-dependent tobacco callus growth (B, E); and the dark induction of betacyanin synthesis in Amaranthus cotyledons (C, F).
The Influence of 9-tetrahydropyran-2-yl and 9-tetrahydrofuran-2-yl groups on the biological activity of 6-benzyl-(3-hydroxybenzylamino)purine in classical cytokinin bioassays. (A) The effect on chlorophyll retention in excised wheat leaf tips; (B) the growth of cytokinin-dependent tobacco callus; (C) the effect on dark betacyanin synthesis in Amaranthus caudatus cotyledon-hypocotyl explants.
The Influence of 9-tetrahydropyran-2-yl and 9-tetrahydrofuran-2-yl groups on the biological activity of 6-benzyl-(3-hydroxybenzylamino)purine in classical cytokinin bioassays. (A) The effect on chlorophyll retention in excised wheat leaf tips; (B) the growth of cytokinin-dependent tobacco callus; (C) the effect on dark betacyanin synthesis in Amaranthus caudatus cotyledon-hypocotyl explants.
Flavone
CAS number: 525-82-6
Flavone is the simplest member of the class of flavones that consists of 4H-chromen-4-one bearing a phenyl substituent at position 2. It has a role as a metabolite and a nematicide.
Competition curves of naltrexone (◼) and compounds 8 (△), 9 (▼), 10 (+), 12 (▲), 15 (◇), 31 (○) and 32 (●) for [3H]-DAMGO binding to Wistar rat forebrain membranes.
Competition curves of naltrexone (◼) and compounds 8 (△), 9 (▼), 10 (+), 12 (▲), 15 (◇), 31 (○) and 32 (●) for [3H]-DAMGO binding to Wistar rat forebrain membranes.
Sodium (Trihydroxy)phenylborate
CAS number: 52542-80-0
Sodium (trihydroxy)phenylborate, also known as sodium phenylborate trihydrate or sodium 2-hydroxy-5-(trihydroxyboranyl)benzoate, is an organoboron compound commonly used in cosmetics and pharmaceuticals for its anti-inflammatory and antimicrobial properties. It consists of a phenyl ring substituted with hydroxyl groups and a borate moiety, giving it chelating and stabilizing characteristics.
Cross-coupling reaction of a deactivated substrate, p-chloroanisole (12), and sodium phenyltrihydroxyborate mediated by complex 11 in air.
Cross-coupling reaction of a deactivated substrate, p-chloroanisole (12), and sodium phenyltrihydroxyborate mediated by complex 11 in air.
Thermal profile of the reaction of p-chloroanisole (12) and sodium phenyltrihydroxyborate in air mediated by complex 11.
Thermal profile of the reaction of p-chloroanisole (12) and sodium phenyltrihydroxyborate in air mediated by complex 11.
Conduritol A
CAS number: 526-87-4
Conduritol A is a conduritol in which the hydroxy groups at positions 2, 3, and 4 are in a trans,trans,cis- relationship to that at position 1. It has a role as a metabolite.
Structures of all conduritol isomers.
Structures of all conduritol isomers.
2-Methylbenzamide
CAS number: 527-85-5
2-METHYLBENZAMIDE is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. 2-Methylbenzamide (o-Toluamide) has been used in total synthesis of phenolic protoberberine alkaloid, cerasonine.
Synthesis of Toluamide 3
Synthesis of Toluamide 3
Tropane
CAS number: 529-17-9
Tropane is a bicyclic amine with pyrrolidine and piperidine rings, found as esters in plants, and is a precursor to many pharmaceuticals.
Chemical structures of cocaine and other tropane-based DAT inhibitors.
Chemical structures of cocaine and other tropane-based DAT inhibitors.
Representative natural products and biological active compounds with tropane frameworks. Boc=tert-butoxycarbonyl.
Representative natural products and biological active compounds with tropane frameworks. Boc=tert-butoxycarbonyl.
a) A reported strategy and b) our strategy for the construction of functionalized tropane derivatives.
a) A reported strategy and b) our strategy for the construction of functionalized tropane derivatives.
2-Aminobenzaldehyde
CAS number: 529-23-7
2-Aminobenzaldehyde is one of three isomers of aminobenzaldehyde. It is a low-melting yellow solid that is soluble in water.
Reagents and conditions: (a) LHMDS, THF, -78 °C to rt, 20%; (b) 2-aminonicotinaldehyde or 2-aminobenzaldehyde, KOH, EtOH, reflux, 47%. (c) ethylsulfonylethene, TEA, MeOH, reflux; (d) 4-fluoro-3-trifluoromethylphenylacetic acid, EDC, HOBt, NMM, DMF, rt, 80–90% two steps. (e) Pd(PPh3)4, CuI, NaCN, MeCN, microwave, 120 °C, 80–90%. Enantiomerically pure products were isolated by chiral phase HPLC.
Reagents and conditions: (a) LHMDS, THF, -78 °C to rt, 20%; (b) 2-aminonicotinaldehyde or 2-aminobenzaldehyde, KOH, EtOH, reflux, 47%. (c) ethylsulfonylethene, TEA, MeOH, reflux; (d) 4-fluoro-3-trifluoromethylphenylacetic acid, EDC, HOBt, NMM, DMF, rt, 80–90% two steps. (e) Pd(PPh3)4, CuI, NaCN, MeCN, microwave, 120 °C, 80–90%. Enantiomerically pure products were isolated by chiral phase HPLC.
Dibenz[a,h]anthracene
CAS number: 53-70-3
Dibenz[a,h]anthracene is an ortho-fused polycyclic arene. It has a role as a mutagen.
N,N-diallyl-p-toluenesulfonamide (5) was cycloisomerized in [D8]toluene (0.17 m) at 50 °C in the presence of B (5 mol%) and 2b (1 equiv). The relative contents of B, G and decomposition products were estimated by 31P NMR spectroscopy with H3PO4 (85%) as external standard and 1,2;5,6-dibenzanthracene (5 mol%) as internal standard.
N,N-diallyl-p-toluenesulfonamide (5) was cycloisomerized in [D8]toluene (0.17 m) at 50 °C in the presence of B (5 mol%) and 2b (1 equiv). The relative contents of B, G and decomposition products were estimated by 31P NMR spectroscopy with H3PO4 (85%) as external standard and 1,2;5,6-dibenzanthracene (5 mol%) as internal standard.