Tropane is a bicyclic amine with pyrrolidine and piperidine rings, found as esters in plants, and is a precursor to many pharmaceuticals.
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Chemical structures of cocaine and other tropane-based DAT inhibitors.
Representative natural products and biological active compounds with tropane frameworks. Boc=tert-butoxycarbonyl.
a) A reported strategy and b) our strategy for the construction of functionalized tropane derivatives.
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