Competition curves of naltrexone (◼) and compounds 8 (△), 9 (▼), 10 (+), 12 (▲), 15 (◇), 31 (○) and 32 (●) for [3H]-DAMGO binding to Wistar rat forebrain membranes.
Hydrazine, anhydrous appears as a colorless, fuming oily liquid with an ammonia-like odor. It can cause cancer according to an independent committee of scientific and health experts.
Hydrazine Scope
Modified diamine catalysts were synthesized starting from the commercial chiral diamine 2. All catalysts except 1a and 1k were easily prepared from 2 in a 4-step sequence as shown in Scheme 2.
Regioselective Synthetic Pathway for 1,3-Disubstituted Tetrahydroindazolones Using Hydrazines 1 and 2-(Hydroxy(N-Boc-pyrrolidin-2-yl)methylene)-5,5-dimethylcyclohexane-1,3-dione 3
Serine is an alpha-amino acid that is alanine substituted at position 3 by a hydroxy group. It has a role as a fundamental metabolite. It is an alpha-amino acid and a polar amino acid. It contains a hydroxymethyl group. It is a conjugate base of a serinium. It is a conjugate acid of a serinate. It is a tautomer of a serine zwitterion.
Structures and function of the target molecules of this study. (A) General structures of the two types of heterocycles created here. (B) Structures of two 1,3,4-oxadiazol-2-ones reported to be inhibitors of serine hydrolases.
5-Nitroimidazole is a nitrogen heterocyclic compound that is a key component in the development of various drugs with antimicrobial, antiparasitic, and antiviral properties.
Tubulysin D is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin D can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis.
N-Phenylindole, also known as 1-Phenyl-1H-indole, is an aromatic organic compound composed of an indole core with a phenyl group attached at the nitrogen atom (N1 position).
Regioselective Electrophilic Palladation at the C3 Position of N-Phenylindole
Crystal structures of 7−10 and the possible pathway to 10 through C3 palladation of N-phenylindole (L1 = OAc, L2 = PivO, L3 = MeO−).
pH-Dependent Highly Regioselective Electrophilic Palladation at the C2 or C3 Position of N-Methylindole and X-ray Crystal Structures of Compounds 12 and 13
Cyanoboron, or more precisely sodium cyanoborohydride (NaCNBH3), is a chemical compound primarily used as a reducing agent in organic synthesis. It's known for being a milder reducing agent than sodium borohydride (NaBH4) and is particularly useful for selectively reducing imines to amines in the presence of other carbonyl compounds like ketones and aldehydes.
Synthesis of diisopropylamine-cyanoborane 1 and diisopropylamino-(cyano)borane 2.