Chemicals list & Research Gallery
CAS number: 3144-16-9
(S)-camphorsulfonic acid is the S enantiomer of camphorsulfonic acid. It is a conjugate acid of a (S)-camphorsulfonate. It is an enantiomer of a (R)-camphorsulfonic acid.
Attempted Mannich-type reaction. DEAD=diethyl azodicarboxylate, dba=(E,E)-dibenzylideneacetone, CSA=camphorsulfonic acid.
CAS number: 3170-80-7
Trichloromethane is an organic chemical compound also known as chloroform. It is a volatile, colorless liquid with a sweet, ether-like odor. While historically used as an anesthetic, its main uses today are as a solvent, a chemical intermediate in various industrial processes, and a precursor in the production of refrigerants and PTFE.
Although phosphonate 6 was acid labile and decomposed overnight in chloroform, it still underwent efficient cross-coupling reactions.
CAS number: 319460-85-0
Axitinib is a Kinase Inhibitor. The mechanism of action of axitinib is as a Receptor Tyrosine Kinase Inhibitor.
Some drugs and drug candidates containing the 1H-indazole structure.
CAS number: 32222-06-3
Calcitriol is a medication that treats low calcium levels caused by kidney disease. It can also treat parathyroid gland conditions.
Enantioselective synthesis of a key A-ring intermediate for the preparation of 1α,25-dihydroxyvitamin D3
α,β-Unsaturated aldehyde 1 serves as a key intermediate in the synthesis of calcitriol.
Structures of 1α,25-dihydroxyvitamin D3 (1) (and its 2R-substituted analogues 2-4), ED-71, and 20-epi-1 (and its 2R-substituted analogues 20-epi-2a and 20-epi-4a -c).
Structures of 1,25-(OH)2D3 (1) and Vitamin D Analogues
Inhibitory effect on the transactivation induced by 1,25-(OH)2D3 (1) was evaluated.
RXRR and SRC-1 recruitment to VDR by 1,25-(OH)2D3 (1) and synthetic compounds (3a-c, 4a-c, 5a-c, and 6a-c) in Cos7 cells.
CAS number: 32264-87-2
2-Cyclobutene-1-one is a cyclic ketone. It features a four-membered ring (cyclobutene) with a ketone group (C=O) attached to one of the carbons.
C C bond cleavage in cyclobutenones and cyclobutanones.
CAS number: 32315-10-9
Triphosgene, also known as bis(trichloromethyl) carbonate, is a chemical compound used as a reagent in organic synthesis, particularly as a safer alternative to the toxic gas phosgene. It's a white, crystalline solid that decomposes to release phosgene at elevated temperatures. This makes it a convenient and safer way to introduce carbonyl groups into molecules.
Synthesis of coronafacic acid ( )-2. The product was obtained as a Et3N salt.
CAS number: 33069-62-4
Paclitaxel is a tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark. It has a role as a microtubule-stabilising agent, a metabolite, a human metabolite and an antineoplastic agent. It is a tetracyclic diterpenoid and a taxane diterpenoid. It is functionally related to a baccatin III.
Action mechanism of 6h for anti-proliferation of NCI-H522 non-small cell lung cancer cells. (A) Compound 6h, vincristine, vinblastine, and paclitaxel were incubated with pure tubulin proteins in GPEM buffer. Alternation of tubulin assembly was recorded at absorbance 340 nm. (B) Cells were treated with vehicle (DMSO, as control), 6h (10, 30, and 100 nM), 100 nM vincristine, and 100 nM paclitaxel for 24 h. Cytosolic (S, soluble) and cytoskeletal (P, polymerized tubulin) fractions were separated and followed by Western blot analysis for detection of a-tubulin, b-tubulin, and b-actin protein expression.
CAS number: 334-88-3
Diazomethane, a yellow gas normally used as a solution in ether, readily esterifies fatty acids in the presence of methanol at room temperature. It is a strong respiratory irritant. Diazomethane is usually prepared by the decomposition of various derivatives of N-methyl-N-nitrosoamines.
Quantum chemically computed Gibbs free-energy pathway for the cyclopropanation of DVTMS by diazomethane.
Quantum chemically computed lowest Gibbs free-energy pathway for the palladium(0)-catalyzed cy-clopropanation of trimethylvinylsilane by diazomethane.
Cycle for the palladium-catalyzed cyclopropanation of DVTMS by diazomethane according to experimental observations and DFT calculations.
CAS number: 33419-42-0
Etoposide is a beta-D-glucoside, a furonaphthodioxole and an organic heterotetracyclic compound. It has a role as an antineoplastic agent and a DNA synthesis inhibitor. It is functionally related to a podophyllotoxin and a 4'-demethylepipodophyllotoxin.
Study of early signaling events of apoptosis induced by compound 6a in Jurkat cells. Cells treated with Etoposide were included as positive control.
Inhibition of topoisomerase by compounds 1-8. Native pBR322 plasmid DNA (-lane) was incubated with 4 units of topoisomerase I (Topo I) and II (Topo II) without (+lane), with control (CT-camptothecin or ET-etoposide), or with drug (lanes 1-8). DNA was analyzed by 1% agarose gel electrophoresis. The gel was stained with ethidium bromide and photographed under UV light.
CAS number: 33543-19-0
1-methoxycyclohexa-1,3-dien-5-yne is a benzyne. It derives from a hydride of a 1,2-didehydrobenzene.
Electronic and steric factors in the reaction of P-vinyl- λ5-phosphazenes and 3-methoxybenzyne.