3-Pyridinyl is a substituted pyridine ring in which a functional group is attached at the third carbon of the six-membered aromatic nitrogen-containing ring. The parent structure, pyridine, is similar to benzene but contains one nitrogen atom replacing a CH group, imparting basicity and unique reactivity. In the 3-pyridinyl configuration (also called meta-pyridyl), the substituent is bonded to the carbon atom adjacent to the nitrogen (but not directly next to it), influencing the molecule's electronic and steric properties. This moiety is commonly found in pharmaceuticals, agrochemicals, and ligands due to its ability to participate in hydrogen bonding, coordination chemistry, and π–π interactions.
Glyoxylic acid is a 2-oxo monocarboxylic acid that is acetic acid bearing an oxo group at the alpha carbon atom. It has a role as a human metabolite, an Escherichia coli metabolite, a Saccharomyces cerevisiae metabolite and a mouse metabolite. It is a 2-oxo monocarboxylic acid and an aldehydic acid. It is a conjugate acid of a glyoxylate.
One-Pot Reaction between Aniline 5a and Glyoxalate 6
Competition curves of naltrexone (◼) and compounds 8 (△), 9 (▼), 10 (+), 12 (▲), 15 (◇), 31 (○) and 32 (●) for [3H]-DAMGO binding to Wistar rat forebrain membranes.
BMS-309403 is a synthetic, cell-permeable, and orally active chemical compound that acts as a potent and selective inhibitor of fatty acid binding protein 4 (FABP4), also known as aP2. It is being researched for its potential in treating conditions like type 2 diabetes and atherosclerosis due to its ability to reduce inflammation and improve insulin sensitivity.
Hydrazine, anhydrous appears as a colorless, fuming oily liquid with an ammonia-like odor. It can cause cancer according to an independent committee of scientific and health experts.
Hydrazine Scope
Modified diamine catalysts were synthesized starting from the commercial chiral diamine 2. All catalysts except 1a and 1k were easily prepared from 2 in a 4-step sequence as shown in Scheme 2.
Regioselective Synthetic Pathway for 1,3-Disubstituted Tetrahydroindazolones Using Hydrazines 1 and 2-(Hydroxy(N-Boc-pyrrolidin-2-yl)methylene)-5,5-dimethylcyclohexane-1,3-dione 3
Serine is an alpha-amino acid that is alanine substituted at position 3 by a hydroxy group. It has a role as a fundamental metabolite. It is an alpha-amino acid and a polar amino acid. It contains a hydroxymethyl group. It is a conjugate base of a serinium. It is a conjugate acid of a serinate. It is a tautomer of a serine zwitterion.
Structures and function of the target molecules of this study. (A) General structures of the two types of heterocycles created here. (B) Structures of two 1,3,4-oxadiazol-2-ones reported to be inhibitors of serine hydrolases.
Novobiocin is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189) Novobiocin sodium, a salt form of novobiocin, was initially approved in September 1964 and was indicated for the treatment of serious infections due to susceptible strains of Staphylococcus aureus when other less toxic antibiotics cannot be used. In 2009, the FDA determined novobiocin sodium was withdrawn from sale for reasons of safety or effectiveness.
5-Nitroimidazole is a nitrogen heterocyclic compound that is a key component in the development of various drugs with antimicrobial, antiparasitic, and antiviral properties.