mGluR5 antagonist-1
CAS number: 2761424-76-2
mGluR5 antagonist-1 is an orally active mGluR5 antagonist with an IC50 value of 11.5 nM. mGluR5 antagonist-1 has anti-depressant effect. mGluR5 antagonist-1 can be used for the study of depressive disorder.
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![Autoradiography on horizontal rat brain slices, indicating heterogeneous distribution of activity with highest uptake in mGluR5-rich regions. The first and second rows represent application of 1 and 10 nM [18F]-16, respectively, and the first and second column represent baseline and blocking conditions, respectively.](http://www.wlxkc.cn/picture/5367115_16.png)
Autoradiography on horizontal rat brain slices, indicating heterogeneous distribution of activity with highest uptake in mGluR5-rich regions. The first and second rows represent application of 1 and 10 nM [18F]-16, respectively, and the first and second column represent baseline and blocking conditions, respectively.
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