Zidovudine is a pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase. It has a role as an antiviral drug, an antimetabolite and a HIV-1 reverse transcriptase inhibitor. It is a pyrimidine 2',3'-dideoxyribonucleoside and an azide.
Several Pharmacologically Useful Agents Containing Uracil and Piperazine Moieties: 5-Fluorouracil, Uramustine, Methylthiouracil, stavudine, zidovudine, prazosin, trazodone, Fluanisone, urapidil.
Thiophene, 2,2′-ethenylidenebis- (C₁₀H₈S₂) is an organosulfur compound consisting of two thiophene rings linked through a vinylidene (-CH=) bridge at their 2-positions. This structure gives it a conjugated π-electron system, which can influence its electronic and optical properties, making it of interest in materials science, especially in organic semiconductors and conductive polymers. It appears as a yellow to orange crystalline solid, is relatively hydrophobic, and is typically synthesized via coupling reactions involving thiophene derivatives.
Phenylthienylethenes 9a,b and dithienylethenes 9c-e.
Topopyrone D is a naphthochromene that is 4H-naphtho[2,3-g]chromene-4,6,11-trione substituted by hydroxy groups at positions 5, 7 and 9 and a methyl group at position 2. It is isolated from fungal strains Phoma and Penicillium and acts as an inhibitor of the enzyme topoisomerase I. It has a role as an antimicrobial agent, an antineoplastic agent, an antiviral agent, an EC 5.99.1.2 (DNA topoisomerase) inhibitor and a Penicillium metabolite. It is a naphthochromene, a member of phenols and a member of p-quinones.
Tubulysin D is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin D can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis.
N-Phenylindole, also known as 1-Phenyl-1H-indole, is an aromatic organic compound composed of an indole core with a phenyl group attached at the nitrogen atom (N1 position).
Regioselective Electrophilic Palladation at the C3 Position of N-Phenylindole
Crystal structures of 7−10 and the possible pathway to 10 through C3 palladation of N-phenylindole (L1 = OAc, L2 = PivO, L3 = MeO−).
pH-Dependent Highly Regioselective Electrophilic Palladation at the C2 or C3 Position of N-Methylindole and X-ray Crystal Structures of Compounds 12 and 13
Cyanoboron, or more precisely sodium cyanoborohydride (NaCNBH3), is a chemical compound primarily used as a reducing agent in organic synthesis. It's known for being a milder reducing agent than sodium borohydride (NaBH4) and is particularly useful for selectively reducing imines to amines in the presence of other carbonyl compounds like ketones and aldehydes.
Synthesis of diisopropylamine-cyanoborane 1 and diisopropylamino-(cyano)borane 2.
Mebendazole is a carbamate ester that is methyl 1H-benzimidazol-2-ylcarbamate substituted by a benzoyl group at position 5. It has a role as an antinematodal drug, a tubulin modulator and a microtubule-destabilising agent. It is a member of benzimidazoles, a carbamate ester and an aromatic ketone. It derives from a hydride of a 1H-benzimidazole.
Complete dissociation of mebendazole (MBZ) ligand from the original framework of complex 1 in DMSO.
(S)-camphorsulfonic acid is the S enantiomer of camphorsulfonic acid. It is a conjugate acid of a (S)-camphorsulfonate. It is an enantiomer of a (R)-camphorsulfonic acid.