Chemicals list & Research Gallery

Sedoheptulose, 7-phosphate
CAS number: 2646-35-7
Sedoheptulose 7-phosphate is a ketoheptose phosphate consisting of sedoheptulose having a phosphate group at the 7-position. It is an intermediate metabolite in the pentose phosphate pathway. It has a role as a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a sedoheptulose derivative and a ketoheptose phosphate. It is functionally related to a sedoheptulose. It is a conjugate acid of a sedoheptulose 7-phosphate(2-).
Natural reactions catalyzed by transaldolases: Erythrose 4-phosphate, Sedoheptulose 7-phosphate, Glyceraldehyde 3-phosphate.
Natural reactions catalyzed by transaldolases: Erythrose 4-phosphate, Sedoheptulose 7-phosphate, Glyceraldehyde 3-phosphate.
Sodium azide
CAS number: 26628-22-8
Sodium azide is the sodium salt of hydrogen azide (hydrazoic acid). It is a fast acting, potentially deadly chemical that is an odorless white solid.
Addition–elimination mechanism for a classical SNAr reaction for para-halogenated nitrobenzene with sodium azide
Addition–elimination mechanism for a classical SNAr reaction for para-halogenated nitrobenzene with sodium azide
SNAr reaction of halogenated benzene with sodium azide under phase-transfer conditions
SNAr reaction of halogenated benzene with sodium azide under phase-transfer conditions
Concerted mechanism for a SNAr reaction for p-Iodo nitrobenzene with sodium azide under mw irradiation
Concerted mechanism for a SNAr reaction for p-Iodo nitrobenzene with sodium azide under mw irradiation
Product obtained in the reaction of pF compounds (R = COH, COCH3) with an excess of sodium azide under different experimental conditions
Product obtained in the reaction of pF compounds (R = COH, COCH3) with an excess of sodium azide under different experimental conditions
Proposed free energy diagrams for the SNAr reactions of sodium azide with different pF compounds.
Proposed free energy diagrams for the SNAr reactions of sodium azide with different pF compounds.
Xanthatin
CAS number: 26791-73-1
Xanthatin is a sesquiterpene lactone. Xanthatin, a sesquiterpene lactone purified from Xanthium strumarium L., possesses a significant antitumor role in several malignant tumors.
Retrosynthetic analysis of xanthatin.
Retrosynthetic analysis of xanthatin.
Synthesis of the bicyclic core structure 2 of xanthatin.
Synthesis of the bicyclic core structure 2 of xanthatin.
Final steps in the synthesis of xanthatin 1a and side-chain analogues 1b–c.
Final steps in the synthesis of xanthatin 1a and side-chain analogues 1b–c.
Etravirine
CAS number: 269055-15-4
Etravirine is an aminopyrimidine that consists of 2,6-diaminopyrimidine bearing a bromo substituent at position 5, a 4-cyano-2,6-dimethylphenoxy substituent at position 4 and having a 4-cyanophenyl substituent attached to the 2-amino group. NNRTI of HIV-1, binds directly to RT and blocks RNA-dependent and DNA-dependent DNA polymerase activities It has a role as a HIV-1 reverse transcriptase inhibitor and an antiviral agent. It is a dinitrile, an organobromine compound, an aminopyrimidine and an aromatic ether.
Chemical structures of DAPY, DATA and target compounds.
Chemical structures of DAPY, DATA and target compounds.
1H-Indazole
CAS number: 271-44-3
1H-indazole is an indazole. It is a tautomer of a 2H-indazole.
Improved Preparation of 2 from Indazole 7
Improved Preparation of 2 from Indazole 7
An Improved Preparation of Indazole 2
An Improved Preparation of Indazole 2
Some drugs and drug candidates containing the 1H-indazole structure.
Some drugs and drug candidates containing the 1H-indazole structure.
The reported strategies for the synthesis of 1H-indazoles.
The reported strategies for the synthesis of 1H-indazoles.
Biologically active compounds containing indazole, indazolone, tetrahydroindazolone, or N-acyl pyrrolidine moieties.
Biologically active compounds containing indazole, indazolone, tetrahydroindazolone, or N-acyl pyrrolidine moieties.
Benzofuran
CAS number: 271-89-6
2,3-Benzofuran is a colorless, sweet-smelling, oily liquid made by processing coal into coal oil. It may also be formed during other uses of coal or oil. 2,3-Benzofuran is not used for any commercial purposes, but the part of the coal oil that contains 2,3-benzofuran is made into a plastic called coumarone-indene resin.
Strategies for the synthesis of indoles and benzofurans.
Strategies for the synthesis of indoles and benzofurans.
Imidazo[4,5-b]pyridine
CAS number: 273-21-2
Imidazo[4,5-b]pyridine is a heterocyclic compound consisting of a pyridine ring fused with an imidazole ring at the 4,5 positions. It's a molecule of interest in medicinal chemistry due to its structural similarity to purines and its diverse biological activities.
Concept: 2- and 6-trifluoromethyl-containing purines and 1-deazapurines as inhibitors of adenosine deaminase (ADA).
Concept: 2- and 6-trifluoromethyl-containing purines and 1-deazapurines as inhibitors of adenosine deaminase (ADA).
Imidazo(1,2-a)pyridine
CAS number: 274-76-0
Imidazo[1,2-a]pyridine is a bicyclic heterocyclic compound consisting of a pyridine ring fused to an imidazole ring.
Approved drugs containing imidazo[1,2-a]pyridines: zolpidem, Zolimidine, Olprinone
Approved drugs containing imidazo[1,2-a]pyridines: zolpidem, Zolimidine, Olprinone
mGluR5 antagonist-1
CAS number: 2761424-76-2
mGluR5 antagonist-1 is an orally active mGluR5 antagonist with an IC50 value of 11.5 nM. mGluR5 antagonist-1 has anti-depressant effect. mGluR5 antagonist-1 can be used for the study of depressive disorder.
Autoradiography on horizontal rat brain slices, indicating heterogeneous distribution of activity with highest uptake in mGluR5-rich regions. The first and second rows represent application of 1 and 10 nM [18F]-16, respectively, and the first and second column represent baseline and blocking conditions, respectively.
Autoradiography on horizontal rat brain slices, indicating heterogeneous distribution of activity with highest uptake in mGluR5-rich regions. The first and second rows represent application of 1 and 10 nM [18F]-16, respectively, and the first and second column represent baseline and blocking conditions, respectively.
Cyclopropene
CAS number: 2781-85-3
Cyclopropene is a cycloalkene that consists of cyclopropane having a double bond in the ring. The parent of the class of cyclopropenes.
Cyclopropene reacts with nitrile imine to form a stable cyclic adduct
Cyclopropene reacts with nitrile imine to form a stable cyclic adduct
Cyclopropene-modified ManNAc derivatives can be metabolically incorporated onto cell surfaces and covalently detected with tetrazine probes.
Cyclopropene-modified ManNAc derivatives can be metabolically incorporated onto cell surfaces and covalently detected with tetrazine probes.
Carbamate-linked cyclopropene sugars label cellular glycoproteins.
Carbamate-linked cyclopropene sugars label cellular glycoproteins.
Distinct metabolic targets can be simultaneously imaged using cyclopropene and azido reporters.
Distinct metabolic targets can be simultaneously imaged using cyclopropene and azido reporters.