Rosaphen, also known as 2-Methyl-5-phenylpentanol, is a fragrance ingredient used in perfumes and cosmetics. It has a rose blossom, slightly waxy odor and is known for its fruity and floral notes. It is not naturally occurring and is typically synthesized via a two-step process involving aldol condensation and hydrogenation.
TEMPO is a member of the class of aminoxyls that is piperidine that carries an oxidanediyl group at position 1 and methyl groups at positions 2, 2, 6, and 6, respectively. It has a role as a ferroptosis inhibitor, a catalyst and a radical scavenger. It is a member of piperidines and a member of aminoxyls.
Reaction between THF and BtH in the Presence of TEMPO
1-Hydroxybenzotriazole is a coupling reagent used to synthesize amides by the condensation reaction between the activated ester/acid and the amino group of protected amino acids. It is also used as a racemization suppressor during peptide synthesis.
JWH-133 is a dibenzopyran that is Delta(9)-tetrahydrocannabinol which is lacking the hydroxy group and in which the pentyl group at position 3 has been replaced by a 1,1-dimethylbutyl group. A potent and highly selective CB2 receptor agonist. It has a role as a CB2 receptor agonist, an antineoplastic agent, a vasodilator agent, an anti-inflammatory agent, an apoptosis inhibitor, an analgesic and an opioid analgesic. It is a dibenzopyran, an organic heterotricyclic compound and a benzochromene.
Representative cannabinoids with various chemical scaffolds: Anandamide, 2-Arachidonylglycerol, Win-55212-2, SR 144528, JWH-133, JTE-907.
Amiloride is a member of the class of pyrazines resulting from the formal monoacylation of guanidine with the carboxy group of 3,5-diamino-6-chloropyrazine-2-carboxylic acid. It has a role as a sodium channel blocker and a diuretic. It is a member of pyrazines, an organochlorine compound, an aromatic amine and a member of guanidines. It is a conjugate base of an amiloride(1+).
Structures of reference agonists (IB-MECA and 2-Cl-IB-MECA) and allosteric modulators (DU 124183, amiloride, and VUF5455) of the A3AR.
Lissamine rhodamine B is a fluorescent dye, specifically a red-fluorescent derivative of rhodamine, used in various applications such as microscopy, flow cytometry, and other assays that require fluorescent detection. It is known for its bright red fluorescence and ability to bind to specific targets or cellular components, making it useful for tracking cellular processes, protein labeling, and tissue staining.
Conjugation of alkyne-terminated OEGs with the tumor-targeting peptide cRGDfK and the fluorescent probe, sulforhodamine B.
Topopyrone A is a naphthochromene that is 4H-naphtho[2,3-h]chromene-4,7,12-trione substituted by a chloro group at position 10, hydroxy groups at positions 5, 9 and 11 and a methyl group at position 2. It is isolated from a fungal strain Phoma sp.BAUA2861 and acts as an inhibitor of the enzyme topoisomerase I. It has a role as a metabolite, an EC 5.99.1.2 (DNA topoisomerase) inhibitor, an antiviral agent, an antineoplastic agent and an antimicrobial agent. It is an organochlorine compound, a naphthochromene, a member of phenols and a member of p-quinones.
Structures of topopyrones A-D: topopyrone A, topopyrone B, topopyrone C, topopyrone D.
Topopyrone B is a naphthochromene that is 4H-naphtho[2,3-g]chromene-4,6,11-trione substituted by a chloro group at position 8, hydroxy groups at positions 5, 7 and 9 and a methyl group at position 2. It is isolated from a fungal strain Phoma sp.BAUA2861 and acts as an inhibitor of the enzyme topoisomerase I. It has a role as a metabolite, an EC 5.99.1.2 (DNA topoisomerase) inhibitor, an antiviral agent, an antineoplastic agent and an antimicrobial agent. It is an organochlorine compound, a naphthochromene, a member of phenols and a member of p-quinones.
Structures of topopyrones A-D: topopyrone A, topopyrone B, topopyrone C, topopyrone D.