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Mycophenolic Acid
CAS number: 24280-93-1
Mycophenolic acid is a potent immunosuppressant agent that inhibits de novo purine biosynthesis. It was derived from Penicillium stoloniferum, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a calcineurin inhibitor (ciclosporin or tacrolimus) and prednisolone.

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Mycophenolic acid (MPA), one of the most potent inhibitors of human IMPDH (Ki ) 10 nM), binds at the NAD binding domain of the enzyme and is used in clinic as an immunosuppressant. C2-MAD was found to be more potent than MPA in both antileukemic activity and the ability to induce differentiation.
Mycophenolic acid (MPA), one of the most potent inhibitors of human IMPDH (Ki ) 10 nM), binds at the NAD binding domain of the enzyme and is used in clinic as an immunosuppressant. C2-MAD was found to be more potent than MPA in both antileukemic activity and the ability to induce differentiation.
We replaced the carboxylic group of MPA with a hydroxamic acid moiety and synthesized hydroxamic acid analogue 9 (MAHA, Figure 4).
We replaced the carboxylic group of MPA with a hydroxamic acid moiety and synthesized hydroxamic acid analogue 9 (MAHA, Figure 4).

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