Chemicals list & Research Gallery

2H-Chromene
CAS number: 254-04-6
2H-chromene is a simplest member of the class of chromene in which the heterocyclic pyran ring has a double bond between positions 3 and 4. It is a chromene and an organic heterobicyclic compound. It is a tautomer of a 4H-chromene.
Proposed studies and spirofuran and benzopyran heterocycles.
Proposed studies and spirofuran and benzopyran heterocycles.
Preferential benzopyran formation.
Preferential benzopyran formation.
Pyrimido[5,4-d]pyrimidine
CAS number: 254-82-0
Pyrimido[5,4-d]pyrimidine is a bicyclic heterocycle composed of fused pyrimidine and pyrimidine rings. It is a biologically important molecule with diverse pharmacological applications, particularly as a core structure for various drug candidates.
The formation of the pyrimido[5,4-d]pyrimidine 6 can be envisaged through the mechanism described in Scheme 2.
The formation of the pyrimido[5,4-d]pyrimidine 6 can be envisaged through the mechanism described in Scheme 2.
3-Propyl-3-buten-2-one
CAS number: 25409-10-3
3-Propyl-3-buten-2-one is also known as 3-methylene-2-hexanone. It is an unsaturated ketone, characterized by a double bond (alkene) and a ketone functional group.
Profile of baker’s yeast reduction of: (a) 3-propyl-3-buten-2-one 2a; (b) 1-phenyl-2-propyl-2-propen-1-one 2h.
Profile of baker’s yeast reduction of: (a) 3-propyl-3-buten-2-one 2a; (b) 1-phenyl-2-propyl-2-propen-1-one 2h.
Tetrahydroquinoline
CAS number: 25448-04-8
Tetrahydroquinoline is an organic compound and a bicyclic molecule derived from quinoline by hydrogenation of the aromatic ring. It's a colorless oil that is a semi-hydrogenated derivative of quinoline.
Preparation of THQ cores 10, 11 and 12.
Preparation of THQ cores 10, 11 and 12.
Attachment of HDAC Pharmacophore to the THQ 4-position.
Attachment of HDAC Pharmacophore to the THQ 4-position.
Comparison between a catalytic amount and a stoichiometric amount of o-chloranil in the oxidation of tetrahydroquinoline derivative.
Comparison between a catalytic amount and a stoichiometric amount of o-chloranil in the oxidation of tetrahydroquinoline derivative.
Cyclohexenol
CAS number: 25512-63-4
Cyclohexen-1-ol is a cyclic alcohol with a double bond, specifically it is a cyclohexene molecule with a hydroxyl group (-OH) attached to one of the carbon atoms in the ring.
Preparation of cyclohexenol 16. DMAP=4-(dimethylamino)-pyridine, Cbz=benzyloxycarbonyl, THF=tetrahydrofuran, TBS=tert-butyldimethylsilyl, dppf=1,1'-bis(diphenylphosphino)ferrocene.
Preparation of cyclohexenol 16. DMAP=4-(dimethylamino)-pyridine, Cbz=benzyloxycarbonyl, THF=tetrahydrofuran, TBS=tert-butyldimethylsilyl, dppf=1,1'-bis(diphenylphosphino)ferrocene.
Ibotenic Acid
CAS number: 2552-55-8
Ibotenic acid is a non-proteinogenic alpha-amino acid. It has a role as a neurotoxin.
We have discovered a versatile and economical synthesis for the preparation of a large variety of homochiral compounds in which a heterocyclic ring system is fused to the β-carbon atom of L-alanine. This methodology has recently been extended to encompass the preparation of analogues of the lower homologue, ibotenic acid. The synthesis, shown in Scheme 1, involves reaction of bisnucleophiles with an aldehyde of a pyroglutamic acid derivative 3 (n = 1) or an aldehyde of a β-lactam 3 (n = 0) or with their homologues 11.
We have discovered a versatile and economical synthesis for the preparation of a large variety of homochiral compounds in which a heterocyclic ring system is fused to the β-carbon atom of L-alanine. This methodology has recently been extended to encompass the preparation of analogues of the lower homologue, ibotenic acid. The synthesis, shown in Scheme 1, involves reaction of bisnucleophiles with an aldehyde of a pyroglutamic acid derivative 3 (n = 1) or an aldehyde of a β-lactam 3 (n = 0) or with their homologues 11.
Propidium Iodide
CAS number: 25535-16-4
Propidium Iodide is a fluorescent nucleic acid dye which binds only to double-stranded nucleic acids. It is commonly used to determine the DNA content of a cell or to discriminate viable from non-viable cells.
Membrane phosphatidylserine expression after treatment of Jurkat cells with compounds 5e, 5i and 6a. Jurkat cells were treated for 48 h with the indicated compounds and doses and the percentages of apoptotic cells was measured by flow cytometry after double staining with propidium iodide and Annexin-V-Fluos.
Membrane phosphatidylserine expression after treatment of Jurkat cells with compounds 5e, 5i and 6a. Jurkat cells were treated for 48 h with the indicated compounds and doses and the percentages of apoptotic cells was measured by flow cytometry after double staining with propidium iodide and Annexin-V-Fluos.
Effect of indicated compounds on primary lymphocytes and Jurkat cells. Primary cell line N1 and Jurkat cells were treated for 48 h at the indicated doses of compounds 5e, 5i and 6a and cell cycles were analysed by flow cytometry after staining with propidium Iodide.
Effect of indicated compounds on primary lymphocytes and Jurkat cells. Primary cell line N1 and Jurkat cells were treated for 48 h at the indicated doses of compounds 5e, 5i and 6a and cell cycles were analysed by flow cytometry after staining with propidium Iodide.
Rosaphen
CAS number: 25634-93-9
Rosaphen, also known as 2-Methyl-5-phenylpentanol, is a fragrance ingredient used in perfumes and cosmetics. It has a rose blossom, slightly waxy odor and is known for its fruity and floral notes. It is not naturally occurring and is typically synthesized via a two-step process involving aldol condensation and hydrogenation.
The designed synthesis of Rosaphen
The designed synthesis of Rosaphen
Tempo
CAS number: 2564-83-2
TEMPO is a member of the class of aminoxyls that is piperidine that carries an oxidanediyl group at position 1 and methyl groups at positions 2, 2, 6, and 6, respectively. It has a role as a ferroptosis inhibitor, a catalyst and a radical scavenger. It is a member of piperidines and a member of aminoxyls.
Reaction between THF and BtH in the Presence of TEMPO
Reaction between THF and BtH in the Presence of TEMPO
1-Hydroxybenzotriazole
CAS number: 2592-95-2
1-Hydroxybenzotriazole is a coupling reagent used to synthesize amides by the condensation reaction between the activated ester/acid and the amino group of protected amino acids. It is also used as a racemization suppressor during peptide synthesis.
Attempted amino acid coupling: glycine ethyl ester, N,N'-dicyclohexyl carbodiimide (DCCI) or 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDAC), 1-hydroxybenzotriazole (HOBt), water, room temperature.
Attempted amino acid coupling: glycine ethyl ester, N,N'-dicyclohexyl carbodiimide (DCCI) or 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDAC), 1-hydroxybenzotriazole (HOBt), water, room temperature.
Synthesis of Dap dipeptides.
Synthesis of Dap dipeptides.