1-Acetylaspidoalbidine is a member of carbazoles. It was first isolated from the plant Vallesia dichotoma. It is closely related to fendleridine (aspidoalbidine), with both compounds sharing a common core structure and being part of the aspidoalbine family.
Structures of (±)-1-acetylaspidoalbidine and (±)-1-methylaspidospermidine.
The total synthesis of (±)-1-acetylaspidoalbidine and (±)-1-methylaspidospermidine.
3H-Indazol-3-one is a chemical compound characterized by a indazole core with a ketone group at the 3-position. It's a nitrogen-containing heterocycle, specifically a dihydroindazolone, and is known for its potential biological activities.
Biologically active compounds containing indazole, indazolone, tetrahydroindazolone, or N-acyl pyrrolidine moieties.
Urea is a carbonyl group with two C-bound amine groups. The commercially available fertilizer has an analysis of 46-0-0 (N-P2O5-K2O). It has a role as a flour treatment agent, a human metabolite, a Daphnia magna metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a mouse metabolite and a fertilizer. It is a monocarboxylic acid amide and a one-carbon compound. It is functionally related to a carbonic acid. It is a tautomer of a carbamimidic acid.
Vincristine is an antitumor vinca alkaloid isolated from Vinca Rosea. It is marketed under several brand names, many of which have different formulations such as Marqibo (liposomal injection) and Vincasar.
Action mechanism of 6h for anti-proliferation of NCI-H522 non-small cell lung cancer cells. (A) Compound 6h, vincristine, vinblastine, and paclitaxel were incubated with pure tubulin proteins in GPEM buffer. Alternation of tubulin assembly was recorded at absorbance 340 nm. (B) Cells were treated with vehicle (DMSO, as control), 6h (10, 30, and 100 nM), 100 nM vincristine, and 100 nM paclitaxel for 24 h. Cytosolic (S, soluble) and cytoskeletal (P, polymerized tubulin) fractions were separated and followed by Western blot analysis for detection of a-tubulin, b-tubulin, and b-actin protein expression.