Chemicals list & Research Gallery
CAS number: 437742-34-2
Salinosporamide A is a salinosporamide in which the core (1R)-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione skeleton is substituted at positions 1, 4, and 5 by (1S)-cyclohex-2-en-1-yl(hydroxy)methyl, 2-chloroethyl, and methyl groups, respectively (the 1R,4R,5S diastereoisomer). A potent proteasome inhibitor, it has attracted interest for potential use in the treatment of various cancers. It has a role as an antineoplastic agent and a proteasome inhibitor. It is a salinosporamide, an organochlorine compound, an organic heterobicyclic compound, a beta-lactone and a gamma-lactam.
Proteasome inhibitors containing fused γ-lactam β-lactone bicyclic ring: Omuralide, salinosporamide A, salinosporamide B, cinnabaramide A, cinnabaramide B, cinnabaramide C
CAS number: 438190-29-5
(Z)-SMI-4a, chemically named (5Z)-5-[3-(trifluoromethyl)benzylidene]-1,3-thiazolidine-2,4-dione, is a synthetic small-molecule inhibitor primarily known for targeting 3-phosphoinositide-dependent protein kinase-1 (PDK1), a key regulator in the PI3K/Akt signaling pathway that is often dysregulated in cancer.
Small molecule inhibitors targeting Pim family kinases: SGI-1776, SMI-4a, K00486, CX-6258, DHPCC-9
CAS number: 443971-71-9
Taibaihenryiin C is a novel diterpenoid with a unique skeletal structure. A diterpenoid is a naturally occurring compound built from four isoprene units, creating a 20-carbon skeleton.
Selected Targets for TADA Str a tegy: Taibaihenryiin C, Kaurane, Leucamenin F
CAS number: 444731-52-6
Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009.
Structures of representative kinase inhibitors containing aminopyrimidine nuclei: Palbociclib, Momelotinib, Pazopanib, Alisertib
CAS number: 44565-77-7
2-Propenamide, N-ethenyl- is a chemical compound also known as N-vinyl-2-propenamide or N-vinyl acrylamide. It's a molecule formed by attaching an ethenyl (vinyl) group to the nitrogen atom of 2-propenamide (also known as acrylamide).
Initial observation of unexpected N-vinylacrylamide formation.
CAS number: 4562-27-0
Pyrimidin-4(3H)-one, also known as 4-Hydroxypyrimidine, is a pyrimidine derivative. It exists in a tautomeric equilibrium with its keto form, 4(3H)-pyrimidinone.
Pyrimidin-4(3H)-ones 3a–e from reaction of N-imidoylthioureas 2a–e with 1.
CAS number: 45738-06-5
1-Oxoisoindole, also known as isoindolin-1-one, is a derivative of isoindole, specifically the 2,3-dihydro-1H-isoindole where the hydrogen at position 1 is replaced by an oxo (C=O) group.
The aldehyde isoindolone was synthesized by the route suggested by retrosynthetic analysis as shown in Scheme 2.
CAS number: 459-73-4
Glycine ethyl ester (GEE) is used in conjunction with N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide (EDC) for carboxyl-footprinting studies of proteins.
Attempted amino acid coupling: glycine ethyl ester, N,N'-dicyclohexyl carbodiimide (DCCI) or 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDAC), 1-hydroxybenzotriazole (HOBt), water, room temperature.
CAS number: 4602-84-0
Farnesol is a farnesane sesquiterpenoid that is dodeca-2,6,10-triene substituted by methyl groups at positions 3, 7 and 11 and a hydroxy group at position 1. It has a role as a plant metabolite, a fungal metabolite and an antimicrobial agent. It is a farnesane sesquiterpenoid, a primary alcohol and a polyprenol.
Attempted Carbocyclization Cascade of Farnesol-Tethered Ynamide 59
CAS number: 461-72-3
Hydantoin is an imidazolidine-2,4-dione.
Synthesis of Akaloid (1): Formation of Hydantoin (7)