Chemicals list & Research Gallery
CAS number: 2609-46-3
Amiloride is a member of the class of pyrazines resulting from the formal monoacylation of guanidine with the carboxy group of 3,5-diamino-6-chloropyrazine-2-carboxylic acid. It has a role as a sodium channel blocker and a diuretic. It is a member of pyrazines, an organochlorine compound, an aromatic amine and a member of guanidines. It is a conjugate base of an amiloride(1+).
Structures of reference agonists (IB-MECA and 2-Cl-IB-MECA) and allosteric modulators (DU 124183, amiloride, and VUF5455) of the A3AR.
CAS number: 2609-88-3
Lissamine rhodamine B is a fluorescent dye, specifically a red-fluorescent derivative of rhodamine, used in various applications such as microscopy, flow cytometry, and other assays that require fluorescent detection. It is known for its bright red fluorescence and ability to bind to specific targets or cellular components, making it useful for tracking cellular processes, protein labeling, and tissue staining.
Conjugation of alkyne-terminated OEGs with the tumor-targeting peptide cRGDfK and the fluorescent probe, sulforhodamine B.
CAS number: 26216-91-1
2-Phenylindoline is a partially saturated derivative of indole, characterized by a fused benzene and pyrrolidine ring system.
Resolution of racemic 2-phenylindoline (8).
CAS number: 264-54-0
1-benzazepine is a mancude organic heterobicyclic parent, a benzazepine and a polycyclic heteroarene.
Asymmetric synthesis of benzazepines 1a–g and benzazepines 2a,b.
CAS number: 26628-22-8
Sodium azide is the sodium salt of hydrogen azide (hydrazoic acid). It is a fast acting, potentially deadly chemical that is an odorless white solid.
Addition–elimination mechanism for a classical SNAr reaction for para-halogenated nitrobenzene with sodium azide
SNAr reaction of halogenated benzene with sodium azide under phase-transfer conditions
Concerted mechanism for a SNAr reaction for p-Iodo nitrobenzene with sodium azide under mw irradiation
Product obtained in the reaction of pF compounds (R = COH, COCH3) with an excess of sodium azide under different experimental conditions
Proposed free energy diagrams for the SNAr reactions of sodium azide with different pF compounds.
CAS number: 26791-73-1
Xanthatin is a sesquiterpene lactone. Xanthatin, a sesquiterpene lactone purified from Xanthium strumarium L., possesses a significant antitumor role in several malignant tumors.
Retrosynthetic analysis of xanthatin.
Synthesis of the bicyclic core structure 2 of xanthatin.
Final steps in the synthesis of xanthatin 1a and side-chain analogues 1b–c.
CAS number: 269055-15-4
Etravirine is an aminopyrimidine that consists of 2,6-diaminopyrimidine bearing a bromo substituent at position 5, a 4-cyano-2,6-dimethylphenoxy substituent at position 4 and having a 4-cyanophenyl substituent attached to the 2-amino group. NNRTI of HIV-1, binds directly to RT and blocks RNA-dependent and DNA-dependent DNA polymerase activities It has a role as a HIV-1 reverse transcriptase inhibitor and an antiviral agent. It is a dinitrile, an organobromine compound, an aminopyrimidine and an aromatic ether.
Chemical structures of DAPY, DATA and target compounds.
CAS number: 271-44-3
1H-indazole is an indazole. It is a tautomer of a 2H-indazole.
Improved Preparation of 2 from Indazole 7
An Improved Preparation of Indazole 2
Some drugs and drug candidates containing the 1H-indazole structure.
The reported strategies for the synthesis of 1H-indazoles.
Biologically active compounds containing indazole, indazolone, tetrahydroindazolone, or N-acyl pyrrolidine moieties.
CAS number: 271-89-6
2,3-Benzofuran is a colorless, sweet-smelling, oily liquid made by processing coal into coal oil. It may also be formed during other uses of coal or oil. 2,3-Benzofuran is not used for any commercial purposes, but the part of the coal oil that contains 2,3-benzofuran is made into a plastic called coumarone-indene resin.
Strategies for the synthesis of indoles and benzofurans.
CAS number: 273-21-2
Imidazo[4,5-b]pyridine is a heterocyclic compound consisting of a pyridine ring fused with an imidazole ring at the 4,5 positions. It's a molecule of interest in medicinal chemistry due to its structural similarity to purines and its diverse biological activities.
Concept: 2- and 6-trifluoromethyl-containing purines and 1-deazapurines as inhibitors of adenosine deaminase (ADA).