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FR901464
CAS number: 146478-72-0
FR901464 is a spiro-epoxide with potent anticancer activity that lowers the mRNA levels of oncogenes and tumour supressor genes. It is isolated from Pseudomonas sp. no.2663. It has a role as an antimicrobial agent, an antineoplastic agent and a bacterial metabolite. It is an acetate ester, a cyclic hemiketal, a member of pyrans, a monocarboxylic acid amide and a spiro-epoxide.

Related images

First Generation Retrosynthetic Analysis of FR901464
First Generation Retrosynthetic Analysis of FR901464
Our First Synthesis of FR901464
Our First Synthesis of FR901464
Summary of the Total Synthesis of FR901464
Summary of the Total Synthesis of FR901464
Final Stage of the Total Synthesis of FR901464
Final Stage of the Total Synthesis of FR901464
Growth inhibition of MCF-7 cells by FR901464 (blue squares) and meayamycin (97; red circles).
Growth inhibition of MCF-7 cells by FR901464 (blue squares) and meayamycin (97; red circles).

Related Questions and Answers

Q: Why is FR901464 significant?
A: FR901464 is a natural product known for its antiproliferative activity against human cancer cells at single-digit nanomolar concentrations. Its target was identified in 2007 as splicing factor 3B subunit 1 (SF3B1), a protein in the human spliceosome.