How does indole-3-acetic acid (IAA) exert a protective effect against high-intensity-exercise-induced liver dysfunction?

Label:chem

Topic
Indole-3-acetic acid (IAA) is a metabolite of tryptophan that has been shown to act as a ligand for the aryl hydrocarbon receptor (AhR), a transcription factor involved in mediating cellular responses. This study explores the role of IAA in protecting against liver dysfunction caused by high-intensity exercise (HIE).

From: "L-Tryptophan-Rich Diet Alleviates High-Intensity-Exercise-Induced Liver Dysfunction via the Metabolite Indole-3-Acetic Acid and AhR Activation", Cells 2025, 14(8), 605;
Answer
IAA exerts a protective effect against HIE-induced liver dysfunction by activating AhR. This activation helps reduce liver inflammation and oxidative stress, as evidenced by decreased levels of pro-inflammatory cytokines and increased levels of anti-inflammatory cytokines. Additionally, IAA supplementation improves liver function by reducing serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST).
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