How does the knockout of the swnR gene affect the morphology and growth rate of Alternaria oxytropis OW7.8?

Label:chem

Topic
The swnR gene in Alternaria oxytropis OW7.8 is involved in the biosynthesis of swainsonine (SW), a toxic alkaloid. To understand the broader impact of the swnR gene, the study examines the morphological and growth characteristics of the wild-type strain and the swnR knockout mutant (∆swnR).

From: "The Effect of the swnR Gene on Swainsonine Biosynthesis in Alternaria oxytropis OW7.8, an Endophytic Fungus of Oxytropis glabra", Microorganisms 2025, 13(6), 1326;
Answer
The knockout of the swnR gene in Alternaria oxytropis OW7.8 results in distinct morphological alterations, including changes in colony and mycelial structure. The ∆swnR mutant exhibits slower growth rates, raised and pale yellow colonies with irregular margins, and short, swollen-tip hyphae in granular arrangements without pigment accumulation. These changes indicate that the swnR gene not only affects SW biosynthesis but also influences fungal morphology and growth.
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