What is the relationship between melatonin use and cataract risk?

Label:chem

Topic
Oxidative stress has been shown to play an important role in the development of cataracts. Melatonin is an endogenous hormone that has antioxidant and anti-inflammatory properties, which may counteract oxidative stress. However, the association between melatonin use and cataract risk in humans has not been well-established.

From: "Association Between Melatonin Use and Cataract Risk: A Target Trial Emulation Retrospective Cohort Study", Antioxidants 2025, 14(8), 1016;
Answer
The study found that melatonin use is associated with a reduced risk of cataracts, suggesting a potential protective effect. This was observed across different cataract subtypes and in subgroup analyses of age, sex, and race.
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