How do silver (Ag) and gold (Au) nanoparticles enhance the detection of adenine in bacterial cells using SERS?

Label:chem

Topic
Silver and gold nanoparticles are used in SERS to enhance the Raman signal, allowing for the detection of trace amounts of metabolites like adenine. The study uses spherical Ag and Au nanoparticles synthesized via a modified Lee–Meisel protocol, which remain stable over an extended period.

From: "Surface-Enhanced Raman Spectroscopy for Adenine Detection in Five Selected Bacterial Strains Under Stress Conditions", Sensors 2025, 25(15), 4629;
Answer
Silver nanoparticles (Ag-NPs) provide high sensitivity and can detect trace amounts of adenine even under non-stress conditions. Gold nanoparticles (Au-NPs) enable selective detection of adenine specifically under stress conditions. This selective detection by Au-NPs suggests their potential use in distinguishing stress states in bacterial cells.
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