What are the differential metabolites (DEMs) associated with swainsonine (SW) biosynthesis in Alternaria oxytropis OW7.8 and its swnR knockout mutant (∆swnR)?

Label:chem

Topic
Metabolomic analysis was conducted to identify metabolites that are differentially accumulated between Alternaria oxytropis OW7.8 and its swnR knockout mutant (∆swnR) to understand the metabolic changes associated with swainsonine (SW) biosynthesis.

From: "The Effect of the swnR Gene on Swainsonine Biosynthesis in Alternaria oxytropis OW7.8, an Endophytic Fungus of Oxytropis glabra", Microorganisms 2025, 13(6), 1326;
Answer
Metabolomic profiling revealed 1626 differential metabolites (DEMs) between A. oxytropis OW7.8 and ∆swnR, with 1005 upregulated and 621 downregulated metabolites in ∆swnR. Five key DEMs closely linked to SW biosynthesis were identified: L-lysine, L-glutamic acid, saccharopine, and L-proline were upregulated, while L-pipecolic acid was downregulated in ∆swnR. These metabolites are crucial precursors or intermediates in the SW biosynthetic pathway, highlighting the impact of the swnR gene on SW metabolism.
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