What are the advantages of using SERS over conventional Raman spectroscopy for detecting bacterial metabolites like adenine?

Label:chem

Topic
Conventional Raman spectroscopy often suffers from weak signals, making it difficult to achieve the sensitivity and specificity needed for reliable bacterial discrimination. SERS overcomes this limitation by significantly enhancing the Raman signal, allowing for the detection of even trace amounts of metabolites.

From: "Surface-Enhanced Raman Spectroscopy for Adenine Detection in Five Selected Bacterial Strains Under Stress Conditions", Sensors 2025, 25(15), 4629;
Answer
SERS offers higher sensitivity and specificity compared to conventional Raman spectroscopy. It enables the detection of adenine as a stress marker in bacterial cells, which is not detectable by conventional Raman spectroscopy. This enhanced detection capability makes SERS a more effective tool for analyzing bacterial stress responses and metabolic activities.
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