What role does L-tryptophan play in alleviating high-intensity-exercise-induced liver dysfunction?

Label:chem

Topic
L-tryptophan is an essential amino acid that plays a crucial role in various metabolic processes and has been shown to have beneficial effects on metabolic disorders, inflammatory injuries, and oxidative stress in several organs. This study investigates whether an L-tryptophan-rich diet can alleviate liver dysfunction caused by high-intensity exercise (HIE) and explores the underlying mechanisms.

From: "L-Tryptophan-Rich Diet Alleviates High-Intensity-Exercise-Induced Liver Dysfunction via the Metabolite Indole-3-Acetic Acid and AhR Activation", Cells 2025, 14(8), 605;
Answer
An L-tryptophan-rich diet significantly alleviates HIE-induced liver dysfunction by increasing the levels of the tryptophan metabolite indole-3-acetic acid (IAA), which activates the aryl hydrocarbon receptor (AhR). This mechanism helps reduce liver inflammation and oxidative stress, thereby protecting the liver from HIE-induced damage.
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