What is the role of the swnR gene in the biosynthesis of swainsonine (SW) in Alternaria oxytropis OW7.8?

Label:chem

Topic
Swainsonine (SW) is a toxic alkaloid produced by certain endophytic fungi, including Alternaria oxytropis OW7.8, which is isolated from the locoweed plant Oxytropis glabra. The swnR gene is part of the SWN gene cluster that is believed to be involved in the biosynthesis of SW. This study investigates the functional role of the swnR gene in SW production by creating a knockout mutant (∆swnR) and an overexpression strain (swnR-OE) of A. oxytropis OW7.8.

From: "The Effect of the swnR Gene on Swainsonine Biosynthesis in Alternaria oxytropis OW7.8, an Endophytic Fungus of Oxytropis glabra", Microorganisms 2025, 13(6), 1326;
Answer
The swnR gene plays a crucial role in promoting the biosynthesis of swainsonine (SW) in Alternaria oxytropis OW7.8. The knockout mutant (∆swnR) exhibited significantly reduced SW levels, while the overexpression strain (swnR-OE) showed increased SW production compared to the wild-type strain. This confirms that the swnR gene is essential for SW biosynthesis in this endophytic fungus.
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