What is the role of adenine in detecting bacterial stress responses using Surface-Enhanced Raman Spectroscopy (SERS)?

Label:chem

Topic
Adenine is a key metabolite indicative of stress conditions in bacteria. It can be detected in the bacterial cell and/or released into the environment as a signaling molecule. SERS is a technique that enhances the Raman signal by placing the sample in the proximity of plasmonic nanostructures, enabling more accurate identification of bacteria and their metabolites. This study investigates the metabolic responses of five selected bacterial strains to physiological stress by analyzing the release of adenine using SERS.

From: "Surface-Enhanced Raman Spectroscopy for Adenine Detection in Five Selected Bacterial Strains Under Stress Conditions", Sensors 2025, 25(15), 4629;
Answer
Adenine serves as a stress marker in bacterial cells under stress conditions. SERS enables the detection of adenine released by bacteria under osmotic stress, which is not detectable by conventional Raman spectroscopy. This detection helps in understanding bacterial stress responses and metabolic activities.
Return to Home Chemical List
Knowledge you may be interested in
What is the role of the aryl hydrocarbon receptor (AhR) in the protective effects of an L-tryptophan-rich diet against high-intensity-exercise-induced liver dysfunction? How does indole-3-acetic acid (IAA) exert a protective effect against high-intensity-exercise-induced liver dysfunction? What role does L-tryptophan play in alleviating high-intensity-exercise-induced liver dysfunction? How can L-tryptophan production in Escherichia coli be improved using biosensor-based, high-throughput screening, and metabolic engineering? How does the overexpression of the swnR gene affect the expression of other SW biosynthesis-related genes in Alternaria oxytropis OW7.8? What are the differential metabolites (DEMs) associated with swainsonine (SW) biosynthesis in Alternaria oxytropis OW7.8 and its swnR knockout mutant (∆swnR)? What are the differentially expressed genes (DEGs) associated with swainsonine (SW) biosynthesis in Alternaria oxytropis OW7.8 and its swnR knockout mutant (∆swnR)? How does the knockout of the swnR gene affect the morphology and growth rate of Alternaria oxytropis OW7.8? What is the role of the swnR gene in the biosynthesis of swainsonine (SW) in Alternaria oxytropis OW7.8? How does swainsonine induce oxidative stress in mice? How do silver (Ag) and gold (Au) nanoparticles enhance the detection of adenine in bacterial cells using SERS? What are the advantages of using SERS over conventional Raman spectroscopy for detecting bacterial metabolites like adenine? How does osmotic stress induced by deionized (DI) water affect the detection of adenine in bacterial cells using SERS? What are the potential applications of SERS in clinical diagnostics and point-of-care (POC) screening? What is the relationship between melatonin use and cataract risk? How does melatonin potentially reduce the risk of cataracts? What were the primary outcomes of the study regarding melatonin use and cataract risk? How was the study designed to minimize bias in the analysis of melatonin use and cataract risk? What role does melatonin play in regulating circadian rhythms and cardiovascular health? What are the roles of superoxide dismutase isoforms (SOD1 and SOD3) and glutathione (GSH) in amniotic fluid (AF) during fetal gastrointestinal development?