What is the role of the aryl hydrocarbon receptor (AhR) in the protective effects of an L-tryptophan-rich diet against high-intensity-exercise-induced liver dysfunction?

Label:chem

Topic
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates various cellular responses, including those related to inflammation and oxidative stress. This study investigates whether AhR activation is involved in the protective effects of an L-tryptophan-rich diet against liver dysfunction caused by high-intensity exercise (HIE).

From: "L-Tryptophan-Rich Diet Alleviates High-Intensity-Exercise-Induced Liver Dysfunction via the Metabolite Indole-3-Acetic Acid and AhR Activation", Cells 2025, 14(8), 605;
Answer
The protective effects of an L-tryptophan-rich diet against HIE-induced liver dysfunction are mediated through AhR activation. The study demonstrates that the AhR inhibitor CH223191 abolishes the protective effects of L-tryptophan supplementation, indicating that AhR activation is crucial for the observed benefits. This suggests that AhR plays a key role in mediating the protective effects of tryptophan metabolites like IAA against liver injury.
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