How does swainsonine affect intestinal permeability in mice?

Label:chem

Topic
Intestinal permeability is crucial for maintaining a healthy gut barrier. Disruption of this barrier can lead to increased absorption of harmful substances such as lipopolysaccharide (LPS), which can trigger systemic inflammation. Swainsonine has been shown to have toxic effects on livestock, but its specific impact on intestinal permeability was not well understood.

From: "Increased intestinal permeability and lipopolysaccharide contribute to swainsonine-induced systemic inflammation", Ecotoxicology and Environmental Safety, Volume 284, 1 October 2024, 116912
Answer
Swainsonine significantly increases intestinal permeability in mice by reducing the number of colonic goblet cells and the abundance of Akkermansia muciniphila, which play essential roles in maintaining intestinal barrier integrity. Additionally, swainsonine up-regulates the mRNA expression of ileal protein tyrosine phosphatase receptor type H (Ptprh) and down-regulates tight junction proteins such as Occludin, Claudin 1, and ZO-1, further impairing intestinal barrier function.
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