What is the role of ferumoxytol in MRI for diagnosing venous thoracic outlet syndrome (TOS)?

Label:chem

Topic
Ferumoxytol is an iron oxide nanoparticle primarily used as a contrast agent for MRI. It is mainly confined to the intravascular compartment upon administration, has a long intravascular half-life of 14-15 hours, and provides a longer period for higher resolution, higher signal-to-noise vascular imaging. This makes it a valuable alternative to gadolinium-based contrast agents, especially for evaluating vascular structures.

From: "Ferumoxytol-enhanced MR venography for diagnosis of venous thoracic outlet syndrome", Radiology Case Reports, Volume 18, Issue 7, July 2023, Pages 2378-2380
Answer
Ferumoxytol is used in MRI to enhance the visualization of vascular structures, particularly in diagnosing venous thoracic outlet syndrome. In this case report, ferumoxytol-enhanced MRI was able to show both chronic subclavian vein thromboses and dynamic occlusion of the subclavian veins with arm abduction, consistent with Paget-Schroetter syndrome. This allowed for a more accurate diagnosis of venous TOS in the patient.
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