How do ropivacaine and lidocaine affect mitochondrial superoxide production in osteosarcoma cells?

Label:chem

Topic
Mitochondrial superoxide production is a key indicator of oxidative stress, which can lead to cellular damage and apoptosis.
Answer
Both ropivacaine and lidocaine significantly enhance mitochondrial superoxide production in SaOS-2 cells, as visualized by increased red fluorescence using the MitoSOX Red probe. This increase in superoxide production contributes to oxidative stress and mitochondrial dysfunction, promoting apoptosis.
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