What is the impact of ropivacaine and lidocaine on mitochondrial morphology in osteosarcoma cells?

Label:chem

Topic
Mitochondrial morphology is closely tied to apoptosis and cellular energy status. Changes in mitochondrial morphology, such as fragmentation, are often associated with increased oxidative stress and apoptosis.
Answer
Ropivacaine and lidocaine induce mitochondrial fragmentation in SaOS-2 cells, as evidenced by a significant reduction in mitochondrial branch counts, branch lengths, and junction counts. This fragmentation is indicative of mitochondrial fission and network disintegration, contributing to the observed apoptotic effects.
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