How do ropivacaine and lidocaine affect alkaline phosphatase (ALP) activity in osteosarcoma cells?

Label:chem

Topic
Alkaline phosphatase (ALP) is a marker of osteoblastic activity in osteosarcoma and is associated with tumor growth and metastatic progression.
Answer
Ropivacaine significantly reduces ALP activity in SaOS-2 cells, indicating an impairment of osteoblastic activity and potentially reducing tumor aggressiveness. Lidocaine, however, does not significantly affect ALP levels at the tested concentrations.
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