What is the impact of ropivacaine and lidocaine on cell migration and invasion in osteosarcoma?

Label:chem

Topic
Osteosarcoma cells are highly invasive, and their ability to migrate and invade is a major factor in metastasis. Matrix metalloproteinases (MMPs) facilitate extracellular matrix remodeling and tumor invasion.
Answer
Ropivacaine and lidocaine inhibit the migration and invasion of SaOS-2 cells. This is evidenced by a significant reduction in cell-free area in Scratch assays and decreased cell invasion in Transwell assays. The inhibitory effects are associated with downregulation of MMP-2 and MMP-9, which are critical for extracellular matrix degradation and tumor invasion.
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