What role do ropivacaine and lidocaine play in inhibiting osteosarcoma cell proliferation and invasion?

Label:chem

Topic
Osteosarcoma is a primary bone malignancy with aggressive local invasion and high metastatic potential. Local anesthetics, such as ropivacaine and lidocaine, have shown anti-proliferative, pro-apoptotic, and anti-metastatic effects in various cancer types, but their impact on osteosarcoma remains poorly understood.
Answer
Ropivacaine and lidocaine significantly reduce cell viability and proliferation in SaOS-2 human osteosarcoma cells. They disrupt mitochondrial function, downregulate matrix metalloproteinases (MMP-2 and MMP-9), and upregulate pro-apoptotic markers (Caspase-3, Caspase-9, and BAX). These effects inhibit cell migration, invasion, and alkaline phosphatase activity, which are hallmarks of osteosarcoma differentiation and metastatic potential.
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