What are the effects of ropivacaine and lidocaine on apoptosis-related gene expression in osteosarcoma cells?

Label:chem

Topic
Apoptosis is a critical process in cancer therapy, and local anesthetics have been shown to influence apoptotic pathways in various cancer types.
Answer
Ropivacaine and lidocaine upregulate pro-apoptotic genes (BAX, Caspase-3, and Caspase-9) and downregulate anti-apoptotic genes (MMP-2 and MMP-9) in SaOS-2 cells. This gene expression profile supports the induction of apoptosis and the inhibition of invasive behavior.
Return to Home Chemical List
Knowledge you may be interested in
How do ropivacaine and lidocaine affect cell proliferation in osteosarcoma? What is the impact of ropivacaine and lidocaine on cell migration and invasion in osteosarcoma? How do ropivacaine and lidocaine affect mitochondrial function in osteosarcoma cells? What role do ropivacaine and lidocaine play in inhibiting osteosarcoma cell proliferation and invasion? How does quinagolide influence feed intake in dairy cows? How does quinagolide affect cell proliferation and apoptosis in the mammary gland? How does prolactin (PRL) influence mammary cell activity and milk production? What is the role of quinagolide in regulating milk production in dairy cows? How does quinagolide affect serum prolactin levels? What is the role of quinagolide in treating endometriosis? How do ropivacaine and lidocaine affect alkaline phosphatase (ALP) activity in osteosarcoma cells? What is the impact of ropivacaine and lidocaine on mitochondrial morphology in osteosarcoma cells? How do ropivacaine and lidocaine affect mitochondrial superoxide production in osteosarcoma cells? What role does ropivacaine play in the treatment of nasopharyngeal carcinoma (NPC)? What is the role of halenaquinone (HQ) in the treatment of leukemia, particularly in Molt 4 cells? What is the role of mifepristone in cervical ripening and labor induction? What is the role of mifepristone and misoprostol in the management of early pregnancy loss (EPL)? What is the role of mifepristone in the management of early pregnancy loss (EPL)? Why is mifepristone not widely used by reproductive endocrinology and infertility specialists for EPL management? How does the combination of mifepristone and misoprostol compare to misoprostol alone in managing EPL?