How do ropivacaine and lidocaine affect cell proliferation in osteosarcoma?

Label:chem

Topic
Proliferation is a key characteristic of cancer cells, and inhibiting this process is a primary goal of cancer therapies. Colony formation assays are used to assess long-term proliferative capacity.
Answer
Both ropivacaine and lidocaine significantly reduce the colony size in a dose-dependent manner, indicating impaired proliferation. Ropivacaine also decreases the number of colonies, suggesting a stronger anti-proliferative effect compared to lidocaine.
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