What role does ropivacaine play in the treatment of nasopharyngeal carcinoma (NPC)?

Label:chem

Topic
Ropivacaine is a long-acting amide-type local anesthetic that exerts its analgesic effects by blocking sodium ion channels and thereby inhibiting nerve impulse transmission. It has also been shown to have antitumor properties by promoting cellular autophagy.
Answer
In this study, ropivacaine is used to inhibit tumor growth and alleviate cancer-related pain in NPC. It is loaded into tumor mitochondrial protein 1 (TMTP1)-modified extracellular vesicles (EVs) to enhance its delivery to tumor cells, thereby improving its therapeutic efficacy and safety.
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