How does the combination of mifepristone and misoprostol compare to misoprostol alone in managing EPL?

Label:chem

Topic
Multiple randomized controlled trials have demonstrated that pretreatment with mifepristone for 24–48 hours followed by misoprostol is more effective than misoprostol monotherapy. The combination regimen results in higher expulsion rates and fewer patients requiring procedural evacuation.
Answer
The combination of mifepristone and misoprostol is significantly more effective in managing EPL compared to misoprostol alone. It achieves successful expulsion in up to 83.8% of patients, compared to 67.1% with misoprostol alone, and reduces the need for surgical intervention.
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