What is the role of quinagolide in regulating milk production in dairy cows?

Label:chem

Topic
Quinagolide is a dopamine D2 receptor agonist used to inhibit the release of prolactin (PRL), a hormone crucial for maintaining lactation in dairy cows. The study investigates how quinagolide affects mammary cell activity, survival, and proliferation.
Answer
Quinagolide reduces milk yield by decreasing the activity, survival, and proliferation of mammary epithelial cells (MEC). It lowers the levels of milk protein transcripts (α-lactalbumin and κ-casein mRNA) and increases apoptosis in the mammary gland, leading to reduced milk production.
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