What is the relationship between Fusobacterium nucleatum infection and glutathione (GSH) levels in gastric cancer (GC)?

Label:chem

Topic
Fusobacterium nucleatum (F. nucleatum) is a Gram-negative anaerobic bacterium that has been associated with tumor progression in colorectal cancer (CRC). Recent studies have shown that F. nucleatum is also enriched in gastric cancer (GC) tissues and is linked to poor patient prognosis. Glutathione (GSH) is a critical intracellular antioxidant that maintains redox homeostasis and plays a dual role in cancer progression. The regulatory mechanism of GSH metabolism in GC and its interaction with F. nucleatum remain unclear.

From: "Fusobacterium nucleatum Infection Drives Glutathione Depletion in Gastric Cancer: Integrated Multi-Omics and Experimental Validation", Microorganisms 2025, 13(8), 1907;
Answer
Fusobacterium nucleatum infection in GC tissues is associated with significant depletion of GSH. The study demonstrates that F. nucleatum suppresses the GSH synthesis pathway, leading to a breakdown in antioxidant capacity and the formation of an oxidative stress microenvironment in GC cells. This finding suggests that targeting the F. nucleatum-GSH axis could offer a novel therapeutic strategy for GC treatment.
Return to Home Chemical List
Knowledge you may be interested in
How do the concentrations of SOD1, SOD3, and 8-OHdG in amniotic fluid (AF) change with gestational age? What are the roles of superoxide dismutase isoforms (SOD1 and SOD3) and glutathione (GSH) in amniotic fluid (AF) during fetal gastrointestinal development? What role does melatonin play in regulating circadian rhythms and cardiovascular health? How was the study designed to minimize bias in the analysis of melatonin use and cataract risk? What were the primary outcomes of the study regarding melatonin use and cataract risk? How does melatonin potentially reduce the risk of cataracts? What is the relationship between melatonin use and cataract risk? What are the potential applications of SERS in clinical diagnostics and point-of-care (POC) screening? How does osmotic stress induced by deionized (DI) water affect the detection of adenine in bacterial cells using SERS? What are the advantages of using SERS over conventional Raman spectroscopy for detecting bacterial metabolites like adenine? What is the mechanism by which Fusobacterium nucleatum depletes glutathione (GSH) in gastric cancer cells? Can the abundance of Fusobacterium nucleatum in gastric cancer tissues serve as a diagnostic biomarker? What therapeutic strategies can be developed based on the F. nucleatum-GSH axis in gastric cancer? How does the clay mineral saponite affect the photodegradation of the biomarker L-histidine under simulated Martian UV conditions? What are the different adsorption mechanisms of L-histidine onto saponite at acidic and basic pH levels? How does the pH level influence the preservation of L-histidine when adsorbed onto saponite under UV irradiation? What is the role of isocyanate additives in asphalt modification? How do isocyanate additives affect the aging behavior of asphalt? How does polyurethane prepolymer (PUP) modify asphalt? What are the limitations of Polyurethane Prepolymer (PUP)-modified asphalt?