How do the concentrations of SOD1, SOD3, and 8-OHdG in amniotic fluid (AF) change with gestational age?

Label:chem

Topic
The study aimed to quantify key antioxidant markers—superoxide dismutase isoforms (SOD1, SOD3), glutathione (GSH), and the oxidative DNA damage marker 8-hydroxy-2-deoxyguanosine (8-OHdG)—in AF across gestational ages. The redox environment of AF is crucial for fetal intestinal development, and understanding its dynamics can provide insights into improving postnatal outcomes, particularly in preterm infants.

From: "Evidence for Extracellular Superoxide Dismutase (SOD3), Glutathione and Redox Dynamics in Amniotic Fluid Throughout Gestation", Children 2025, 12(8), 1086;
Answer
SOD1 and SOD3 concentrations in AF decrease significantly with increasing gestational age (p < 0.001), while 8-OHdG levels increase (p < 0.001). This suggests that the antioxidant environment of AF is dynamic, undergoing substantial modulation of the oxidative–antioxidative balance throughout gestation. The early intrauterine environment is more reliant on antioxidant protection, which diminishes as structural and functional maturation of the fetal gastrointestinal tract progresses.
Return to Home Chemical List
Knowledge you may be interested in
What are the roles of superoxide dismutase isoforms (SOD1 and SOD3) and glutathione (GSH) in amniotic fluid (AF) during fetal gastrointestinal development? What role does melatonin play in regulating circadian rhythms and cardiovascular health? How was the study designed to minimize bias in the analysis of melatonin use and cataract risk? What were the primary outcomes of the study regarding melatonin use and cataract risk? How does melatonin potentially reduce the risk of cataracts? What is the relationship between melatonin use and cataract risk? What are the potential applications of SERS in clinical diagnostics and point-of-care (POC) screening? How does osmotic stress induced by deionized (DI) water affect the detection of adenine in bacterial cells using SERS? What are the advantages of using SERS over conventional Raman spectroscopy for detecting bacterial metabolites like adenine? How do silver (Ag) and gold (Au) nanoparticles enhance the detection of adenine in bacterial cells using SERS? What is the relationship between Fusobacterium nucleatum infection and glutathione (GSH) levels in gastric cancer (GC)? What is the mechanism by which Fusobacterium nucleatum depletes glutathione (GSH) in gastric cancer cells? Can the abundance of Fusobacterium nucleatum in gastric cancer tissues serve as a diagnostic biomarker? What therapeutic strategies can be developed based on the F. nucleatum-GSH axis in gastric cancer? How does the clay mineral saponite affect the photodegradation of the biomarker L-histidine under simulated Martian UV conditions? What are the different adsorption mechanisms of L-histidine onto saponite at acidic and basic pH levels? How does the pH level influence the preservation of L-histidine when adsorbed onto saponite under UV irradiation? What is the role of isocyanate additives in asphalt modification? How do isocyanate additives affect the aging behavior of asphalt? How does polyurethane prepolymer (PUP) modify asphalt?