What role does ferumoxytol play in cardiovascular magnetic resonance imaging (MRI) for congenital heart disease (CHD) patients?

Label:chem

Topic
Ferumoxytol is an ultrasmall superparamagnetic iron oxide (USPIO) contrast agent that has been used to enhance MRI scans. It provides a bright signal in the blood pool, which is crucial for tracking cardiac motion and improving the quality of MRI images. Ferumoxytol has shown promising results in pediatric cardiac MRI, particularly for imaging CHD, enabling sub-millimetric isotropic whole-heart coverage even in very small infants.

From: "Exploring the limits of scan time reduction for ferumoxytol-enhanced whole-heart angiography in congenital heart disease patients",
Journal of Cardiovascular Magnetic Resonance, Volume 27, Issue 1, Summer 2025, 101854
Answer
Ferumoxytol is used to enhance the quality of MRI images in CHD patients by providing a bright signal in the blood pool, which helps in tracking cardiac motion and improving the delineation of cardiac anatomy and vasculature. This enhancement allows for shorter scan times and better image quality, making MRI a more feasible and effective tool for evaluating CHD in both pediatric and adult patients.
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